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. 2016 Nov 8:9:6915-6920.
doi: 10.2147/OTT.S117097. eCollection 2016.

A retrospective analysis of the clinicopathological and molecular characteristics of pulmonary blastoma

Yuan-Yuan Zhao  1 , Lin Liu  2 , Ting Zhou  1 , Ning-Ning Zhou  1 , Yun-Peng Yang  1 , Xue Hou  1 , Yong Li  3 , Hong-Yun Zhao  1 , Yan Huang  1 , Li Zhang  1
Affiliations

A retrospective analysis of the clinicopathological and molecular characteristics of pulmonary blastoma

Yuan-Yuan Zhao et al. Onco Targets Ther. .

Abstract

Purpose: The aim of this study was to analyze and summarize the clinicopathological and molecular characteristics of classic biphasic pulmonary blastoma (PB) to improve its diagnosis and treatment.

Patients and methods: A retrospective analysis was performed in patients who were diagnosed with PB at Sun Yat-Sen University Cancer Center from March 1995 to March 2015. Genomic DNA was profiled using a capture-based targeted sequencing panel.

Results: Sixteen patients with an average age of 40 years were included in this study. Accurate preoperative diagnosis was very challenging as surgically resected tissues with immunohistochemical staining were required for the diagnosis. Surgery was the optimal treatment for localized disease and there was no standard management for metastatic disease. Mutations were detected among 9 out of the 56 genes profiled, including BRCA2, ERBB4, ALK, MET, BRAF, RAF1, PTEN, EGFR, and PIK3CA.

Conclusion: Due to the low incidence rate and the reclassification of PB, no standard treatment is available. Although the numbers of cases are few with varying individual experiences, it is important to improve our understanding regarding this rare lung cancer. Targeted DNA sequencing may be of clinical use for molecular testing and the effects of targeted therapy need to be confirmed.

Keywords: clinicopathological characteristics; molecular characteristics; pulmonary blastoma; targeted DNA sequencing.

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Conflict of interest statement

The authors report no conflicts of interest in this work.

Figures

Figure 1
Figure 1
Pathological examination (hematoxylin and eosin staining) shows a part of carcinoma with slit-formed duct formation and immature mesenchymal cells. (A) 40× and (B) 200×. The malignant glandular component was diffusely positive for epithelial marker (200×): (C) CK, (D) TTF-1, (E) EMA. The malignant stromal component was positive for mesenchymal marker (200×), (F) Vimentin.
Figure 2
Figure 2
Typical CT (computed tomography) images of one of our patients. The CT scan revealed a mass opacity of diameter 80×70 mm in size in the lower lobe of the left lung near the hilar area. (A) Mediastinal window, (B) lung window, and (C–F) CT 3-dimensional reconstructions.
See this image and copyright information in PMC

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