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. 2016 Nov 10:9:443-449.
doi: 10.2147/CCID.S121302. eCollection 2016.

Systemic abnormalities of psoriatic patients: a retrospective study

Li Yin  1 , Jia-Li Xu  2 , Ying-Ying Hu  1 , Andrew Johnston  3 , Zhi-Qiang Yin  1
Affiliations

Systemic abnormalities of psoriatic patients: a retrospective study

Li Yin et al. Clin Cosmet Investig Dermatol. .

Abstract

Background: Psoriasis is a chronic immune-mediated inflammatory disease related to the metabolic syndrome, cardiovascular disease, and other comorbidities. However, so far there has been no specific research concerning systemic abnormalities in psoriatic patients.

Objective: A retrospective study was conducted focusing on the detailed systemic abnormalities in psoriatic patients.

Methods: Psoriatic inpatients data was collected from July 2009 to September 2015. The inclusion criteria were first-time hospitalization and without administration of systemic drug therapy or exposure to phototherapy for psoriasis for at least 1 month. Detailed systemic indexes were mainly evaluated.

Results: The abnormality rates of blood routine examination, urine examination, blood biochemical examination and chest X-ray of 43 psoriatic patients were significantly higher than those of 44 non-psoriasis controls, and psoriasis patients significantly had higher absolute values of leukocytes and neutrophils, and significantly lower values of lymphocytes. Compared with psoriasis vulgaris, erythrodermic psoriasis had significantly higher abnormality rates of blood biochemical examination and serum electrolyte analysis. Erythrodermic psoriasis had significantly higher absolute values of blood leukocytes, neutrophils, and lower serum calcium compared with those of psoriasis vulgaris. The neutrophil-to-lymphocyte ratio of controls was significantly lower than that of psoriatic patients, and neutrophil-to-lymphocyte ratio of erythrodermic psoriasis was significantly higher in comparison with psoriasis vulgaris.

Conclusion: This study is the first report in relation to a detailed assessment of systemic abnormalities in psoriatic patients prior to onset of systemic treatment. The systemic condition of psoriatic patients should be observed by clinicians before systemic therapy.

Keywords: inflammation; psoriasis; skin; treatment.

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Conflict of interest statement

The authors report no conflicts of interest in this work.

Figures

Figure 1
Figure 1
The comparison of abnormality rate between psoriatic patients and non-psoriasis controls. Notes: Statistical significance indicated as *P≤0.05, **P≤ 0.01, ***P≤0.001. Abbreviations: BRE, blood routine examination; UE, urine examination; BBE, blood biochemical examination; CXR, chest X-ray; ECG, electrocardiogram; USG, ultrasonography; LFT, liver function tests; RFT, renal function tests; HDL, high-density lipoprotein.
Figure 2
Figure 2
The comparison of abnormality rate between PV and EP (A), and the comparison between psoriasis with winter flares and non-winter flares (B). Note: Statistical significance indicated as *P≤0.05. Abbreviations: PV, psoriasis vulgaris; EP, erythrodermic psoriasis; BRE, blood routine examination; UE, urine examination; BBE, blood biochemical examination; SEA, serum electrolyte analysis; CXR, chest X-ray; ECG, electrocardiogram; USG, ultrasonography.
Figure 3
Figure 3
Scatter plots of absolute values of peripheral blood leukocyte, lymphocyte, neutrophil, fasting blood glucose, and serum calcium. Notes: (A) The comparison between psoriasis and non-psoriasis controls. (B) The comparison between EP and PV. Statistical significance indicated as *P≤0.05, **P≤ 0.01, *** P≤0.001. Abbreviations: PV, psoriasis vulgaris; EP, erythrodermic psoriasis.
See this image and copyright information in PMC

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