Case Reports
doi: 10.1007/BF00293590.
Three chromosomes' (7;9;22) rearrangement and the origin of the Philadelphia chromosome
- PMID: 278772
- DOI: 10.1007/BF00293590
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Case Reports
Three chromosomes' (7;9;22) rearrangement and the origin of the Philadelphia chromosome
Hum Genet.
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Abstract
A woman with chronic myelocytic leukemia had the Philadelphia chromosome and a complex four-break--three-chromosome rearrangement. The q32 leads to q34 portion of chromosome 9 is translocated to band q22 of chromosome 7, and at the end of this segment is attached the deleted q11 leads to qter portion of chromosome 22. A review of 12 cases of the Philadelphia chromosome originating by the rearrangement of three or more chromosomes reveals that chromosomes 9 and 22 are always involved, while the third chromosome is a different one in each case. We discuss the hypothesis that the 22q segment is always specifically attached to band 9q34 wherever this portion of 9q is transposed.
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