Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Comment
. 2016 Aug;45(4):1298-1301.
doi: 10.1093/ije/dyw194.

Response to: Reliability and validity of telomere length measurements

Simon Verhulst  1 , Ezra Susser  2 , Pam R Factor-Litvak  3 , Mirre Simons  4 , Athanase Benetos  5 , Troels Steenstrup  6 , Jeremy D Kark  7 , Abraham Aviv  8
Affiliations
Comment

Response to: Reliability and validity of telomere length measurements

Simon Verhulst et al. Int J Epidemiol. 2016 Aug.
No abstract available

PubMed Disclaimer

Figures

Figure 1.
Figure 1.
Estimated correlations r and 95% confidence intervals (Y axis) depending on the true value of the correlation being estimated (X axis) for different levels of measurement reliability (ICC values 0.5, 0.75 and 1). The estimates of r deviate more from the true value when the ICC is lower. Increasing sample size (50, 100 or 200) decreases the confidence interval of the estimate, but does not affect the average point estimate. Note that confidence intervals are large relative to the effect of the ICC differences on the r estimates, and hence comparing correlation coefficients will have low statistical power to detect effects of measurement reliability on r. Note further that correlations in epidemiological telomere studies will reach values as high as the upper limit (0.7) in this example only in exceptional circumstances.
See this image and copyright information in PMC

Comment on

References

    1. Eisenberg D. Telomere length measurement validity: the coefficient of variation (CV) is invalid and cannot be used to compare qPCR and Southern blot telomere length measurement techniques. Int J Epidemiol 2016;45:1293–96. - PubMed
    1. Verhulst S, Susser E, Factor-Litvak PR. et al. Commentary: The reliability of telomere length measurements. Int J Epidemiol 2015;44:1683–86. - PMC - PubMed
    1. Gardner M, Bann D, Wiley L. et al. Gender and telomere length: systematic review and meta-analysis. Exp Gerontol 2014;51:15–27. - PMC - PubMed
    1. Steenstrup T, Hjelmborg JV, Kark JD, Christensen K, Aviv A. The telomere lengthening conundrum - artifact or biology? Nucleic Acids Res 2013;41:e131. - PMC - PubMed
    1. Elbers CC, Garcia ME, Kimura M. et al. Comparison between southern blots and qPCR analysis of leukocyte telomere length in the health ABC study. J Gerontol A Biol Sci Med Sci 2014;69:527–31. - PMC - PubMed