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. 1989 Jul;67(3):408-13.

Mouse bone marrow-derived IL-3-dependent mast cells and autonomous sublines produce IL-6

L Hültner  1 , H Szöts, M Welle, J Van Snick, J Moeller, P Dörmer
Affiliations

Mouse bone marrow-derived IL-3-dependent mast cells and autonomous sublines produce IL-6

L Hültner et al. Immunology. 1989 Jul.

Abstract

This study deals with the question of whether mouse bone marrow-derived mast cells are able to produce interleukin-6 (IL-6) in vitro. For this purpose, a panel of primary mast cell clones from limiting-dilution microcultures, of permanent IL-3-dependent mast cell lines and autonomous malignant sublines, was screened. All of these lines were found to produce growth factor activity for IL-6-dependent mouse hybridoma cells (7TD1), which could be completely neutralized by the monoclonal anti-IL-6-antibody 6B4. Transcriptional activity of the IL-6 gene was demonstrated in both IL-3-dependent mast cells and autonomous sublines using a mouse IL-6-specific cDNA probe.

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