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Editorial
. 2017 Feb;28(2):389-393.
doi: 10.1681/ASN.2016091028. Epub 2016 Nov 23.

Genetics of Diabetic Kidney Disease-From the Worst of Nightmares to the Light of Dawn?

Ronald C W Ma  1   2   3 , Mark E Cooper  4
Affiliations
Editorial

Genetics of Diabetic Kidney Disease-From the Worst of Nightmares to the Light of Dawn?

Ronald C W Ma et al. J Am Soc Nephrol. 2017 Feb.
No abstract available

Keywords: chronic diabetic complications; diabetic nephropathy; human genetics; molecular genetics.

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Figures

Figure 1.
Figure 1.
Progress in the identification of genetic loci for DKD. The list of loci and effect estimates are derived mainly from ref. and the original studies cited. Loci with consistent association with the different definitions of DKD are included, with the majority of studies on the basis of DKD being defined as ESRD. Most variants listed, with a few exceptions, have not achieved association at the genome–wide significance threshold. Although the nearest gene to each variant has been indicated, the direct role of the gene listed has not been established at most of the loci. *Discovered/replicated in studies in subjects with T1D. #Discovered/replicated in studies in subjects with T2D. ^Evidence of sex difference in the association signal, with significant association detected only for women.
See this image and copyright information in PMC

Comment on

  • The Genetic Landscape of Renal Complications in Type 1 Diabetes.
    Sandholm N, Van Zuydam N, Ahlqvist E, Juliusdottir T, Deshmukh HA, Rayner NW, Di Camillo B, Forsblom C, Fadista J, Ziemek D, Salem RM, Hiraki LT, Pezzolesi M, Trégouët D, Dahlström E, Valo E, Oskolkov N, Ladenvall C, Marcovecchio ML, Cooper J, Sambo F, Malovini A, Manfrini M, McKnight AJ, Lajer M, Harjutsalo V, Gordin D, Parkkonen M; The FinnDiane Study Group; Tuomilehto J, Lyssenko V, McKeigue PM, Rich SS, Brosnan MJ, Fauman E, Bellazzi R, Rossing P, Hadjadj S, Krolewski A, Paterson AD; The DCCT/EDIC Study Group; Florez JC, Hirschhorn JN, Maxwell AP; GENIE Consortium; Dunger D, Cobelli C, Colhoun HM, Groop L, McCarthy MI, Groop PH; SUMMIT Consortium. Sandholm N, et al. J Am Soc Nephrol. 2017 Feb;28(2):557-574. doi: 10.1681/ASN.2016020231. Epub 2016 Sep 19. J Am Soc Nephrol. 2017. PMID: 27647854 Free PMC article.

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