Considering Sex as a Biological Variable Will Be Valuable for Neuroscience Research

doi:10.1523/JNEUROSCI.1390-16.2016

. 2016 Nov 23;36(47):11817-11822.

doi: 10.1523/JNEUROSCI.1390-16.2016.

Considering Sex as a Biological Variable Will Be Valuable for Neuroscience Research

Rebecca M Shansky¹, Catherine S Woolley²

Affiliations

¹ Department of Psychology, Northeastern University, Boston, Massachusetts 02115, and r.shansky@neu.edu cwoolley@northwestern.edu.
² Department of Neurobiology, Northwestern University, Evanston, Illinois 60208 r.shansky@neu.edu cwoolley@northwestern.edu.

PMID: 27881768
PMCID: PMC5125240
DOI: 10.1523/JNEUROSCI.1390-16.2016

Considering Sex as a Biological Variable Will Be Valuable for Neuroscience Research

Rebecca M Shansky et al. J Neurosci. 2016.

. 2016 Nov 23;36(47):11817-11822.

doi: 10.1523/JNEUROSCI.1390-16.2016.

Authors

Rebecca M Shansky¹, Catherine S Woolley²

Affiliations

¹ Department of Psychology, Northeastern University, Boston, Massachusetts 02115, and r.shansky@neu.edu cwoolley@northwestern.edu.
² Department of Neurobiology, Northwestern University, Evanston, Illinois 60208 r.shansky@neu.edu cwoolley@northwestern.edu.

PMID: 27881768
PMCID: PMC5125240
DOI: 10.1523/JNEUROSCI.1390-16.2016

Abstract

The recently implemented National Institutes of Health policy requiring that grant applicants consider sex as a biological variable in the design of basic and preclinical animal research studies has prompted considerable discussion within the neuroscience community. Here, we present reasons to be optimistic that this new policy will be valuable for neuroscience, and we suggest some ways for neuroscientists to think about incorporating sex as a variable in their research.

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References

1. Abel KM, Drake R, Goldstein JM. Sex differences in schizophrenia. Int Rev Psychiatry. 2010;22:417–428. doi: 10.3109/09540261.2010.515205. - DOI - PubMed
1. Archer J. Rodent sex differences in emotional and related behavior. Behav Biol. 1975;14:451–479. doi: 10.1016/S0091-6773(75)90636-7. - DOI - PubMed
1. Bangasser DA, Wiersielis KR, Khantsis S. Sex differences in the locus coeruleus-norepinephrine system and its regulation by stress. Brain Res. 2016;1641:177–188. doi: 10.1016/j.brainres.2015.11.021. - DOI - PMC - PubMed
1. Becker JB, Koob GF. Sex differences in animal models: focus on addiction. Pharmacol Rev. 2016;68:242–263. doi: 10.1124/pr.115.011163. - DOI - PMC - PubMed
1. Becker JB, Arnold AP, Berkley KJ, Blaustein JD, Eckel LA, Hampson E, Herman JP, Marts S, Sadee W, Steiner M, Taylor J, Young E. Strategies and methods for research on sex differences in brain and behavior. Endocrinology. 2005;146:1650–1673. doi: 10.1210/en.2004-1142. - DOI - PubMed

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[1] Abel KM, Drake R, Goldstein JM. Sex differences in schizophrenia. Int Rev Psychiatry. 2010;22:417–428. doi: 10.3109/09540261.2010.515205. - DOI - PubMed

[2] Abel KM, Drake R, Goldstein JM. Sex differences in schizophrenia. Int Rev Psychiatry. 2010;22:417–428. doi: 10.3109/09540261.2010.515205. - DOI - PubMed

[3] Archer J. Rodent sex differences in emotional and related behavior. Behav Biol. 1975;14:451–479. doi: 10.1016/S0091-6773(75)90636-7. - DOI - PubMed

[4] Archer J. Rodent sex differences in emotional and related behavior. Behav Biol. 1975;14:451–479. doi: 10.1016/S0091-6773(75)90636-7. - DOI - PubMed

[5] Bangasser DA, Wiersielis KR, Khantsis S. Sex differences in the locus coeruleus-norepinephrine system and its regulation by stress. Brain Res. 2016;1641:177–188. doi: 10.1016/j.brainres.2015.11.021. - DOI - PMC - PubMed

[6] Bangasser DA, Wiersielis KR, Khantsis S. Sex differences in the locus coeruleus-norepinephrine system and its regulation by stress. Brain Res. 2016;1641:177–188. doi: 10.1016/j.brainres.2015.11.021. - DOI - PMC - PubMed

[7] Becker JB, Koob GF. Sex differences in animal models: focus on addiction. Pharmacol Rev. 2016;68:242–263. doi: 10.1124/pr.115.011163. - DOI - PMC - PubMed

[8] Becker JB, Koob GF. Sex differences in animal models: focus on addiction. Pharmacol Rev. 2016;68:242–263. doi: 10.1124/pr.115.011163. - DOI - PMC - PubMed

[9] Becker JB, Arnold AP, Berkley KJ, Blaustein JD, Eckel LA, Hampson E, Herman JP, Marts S, Sadee W, Steiner M, Taylor J, Young E. Strategies and methods for research on sex differences in brain and behavior. Endocrinology. 2005;146:1650–1673. doi: 10.1210/en.2004-1142. - DOI - PubMed

[10] Becker JB, Arnold AP, Berkley KJ, Blaustein JD, Eckel LA, Hampson E, Herman JP, Marts S, Sadee W, Steiner M, Taylor J, Young E. Strategies and methods for research on sex differences in brain and behavior. Endocrinology. 2005;146:1650–1673. doi: 10.1210/en.2004-1142. - DOI - PubMed

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Considering Sex as a Biological Variable Will Be Valuable for Neuroscience Research

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Considering Sex as a Biological Variable Will Be Valuable for Neuroscience Research

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