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Editorial
. 2016 Nov 10;7(11):972-973.
doi: 10.1021/acsmedchemlett.6b00421.

Next-Generation Antibody-Drug Conjugates (ADCs) for Cancer Therapy

Jagath Reddy Junutula  1 , Hans-Peter Gerber  2
Affiliations
Editorial

Next-Generation Antibody-Drug Conjugates (ADCs) for Cancer Therapy

Jagath Reddy Junutula et al. ACS Med Chem Lett. .
No abstract available

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References

    1. Sievers E. L.; Senter P. D. Antibody-Drug Conjugates in Cancer Therapy. Annu. Rev. Med. 2013, 64, 15–29. 10.1146/annurev-med-050311-201823. - DOI - PubMed
    1. Gerber H. P.; Koehn F. E.; Abraham R. T. The antibody-drug conjugate: an enabling modality for natural product-based cancer therapeutics. Nat. Prod. Rep. 2013, 30, 625–639. 10.1039/c3np20113a. - DOI - PubMed
    1. Donaghy H. Effects of antibody, drug and linker on the preclinical and clinical toxicities of antibody-drug conjugates. mAbs 2016, 8, 659–671. 10.1080/19420862.2016.1156829. - DOI - PMC - PubMed
    1. https://clinicaltrials.gov.
    1. Junutula J. R.; Raab H.; Clark S.; Bhakta S.; Leipold D. D.; Weir S.; Chen Y.; Simpson M.; Tsai S. P.; Dennis M. S.; Lu Y.; Meng Y. G.; Ng C.; Yang J.; Lee C. C.; Duenas E.; Gorrell J.; Katta V.; Kim A.; McDorman K.; Flagella K.; Ross S.; Venook R.; Spencer S. D.; Wong W. L.; Lowman H. B.; Vandlen R.; Slikowski M. X.; Scheller R. H.; Polakis P.; Malllet W. Site-specific conjugation of cytotoxic drugs to antibodies substantially improves the therapeutic index. Nat. Biotechnol. 2008, 26, 925–932. 10.1038/nbt.1480. - DOI - PubMed

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