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Review
. 2017 Jun;1864(6):907-914.
doi: 10.1016/j.bbamcr.2016.11.017. Epub 2016 Nov 22.

Cardiac inositol 1,4,5-trisphosphate receptors

M Iveth Garcia  1 , Darren Boehning  2
Affiliations
Review

Cardiac inositol 1,4,5-trisphosphate receptors

M Iveth Garcia et al. Biochim Biophys Acta Mol Cell Res. 2017 Jun.

Abstract

Calcium is a second messenger that regulates almost all cellular functions. In cardiomyocytes, calcium plays an integral role in many functions including muscle contraction, gene expression, and cell death. Inositol 1,4,5-trisphosphate receptors (IP3Rs) are a family of calcium channels that are ubiquitously expressed in all tissues. In the heart, IP3Rs have been associated with regulation of cardiomyocyte function in response to a variety of neurohormonal agonists, including those implicated in cardiac disease. Notably, IP3R activity is thought to be essential for mediating the hypertrophic response to multiple stimuli including endothelin-1 and angiotensin II. In this review, we will explore the functional implications of IP3R activity in the heart in health and disease.

Keywords: Calcium channels; Cardiac hypertrophy; IP(3) Receptor.

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Figures

Figure 1
Figure 1. Control of cardiomyocyte function by IP3Rs
Activation of GPCRs coupled to PLC such as the ETA receptor lead to the production of IP3 and diacylglycerol. IP3 then diffuses through the cytosol to bind and activate IP3R channels. IP3-mediated calcium release can modulate CICR and muscle contraction via modulation of RYR activity. Nuclear/perinuclear IP3Rs are tough to modulate gene transcription.
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