Effects in dogs with behavioural disorders of a commercial nutraceutical diet on stress and neuroendocrine parameters

Abstract

The well-being of dogs can be affected by changes in human lifestyle, eating habits and increased stressors that lead to behavioural disorders including fear, hyperactivity and anxiety, followed by negative affective moods and poor welfare. This randomised, controlled clinical evaluation involved 69 dogs, 38 males and 31 females, of different breeds, with behavioural disorders related to anxiety and chronic stress. They were fed a control diet or a nutraceutical diet (ND group) for 45 days. Neuroendocrine (serotonin, dopamine, β-endorphins, noradrenaline and cortisol) and stress (derivatives of reactive oxygen metabolites (dROMs) and biological antioxidant potential (BAP)) parameters related to behavioural disorders were evaluated at the beginning and end of the study period. Results showed a significant increase in serotonin, dopamine and β-endorphins plasma concentrations (*P<0.05, *P<0.05 and **P<0.01, respectively) and a significant decrease in noradrenaline and cortisol plasma concentrations in the ND group (*P<0.05). dROMs significantly decreased in the ND group (*P<0.05) while BAP was not affected. This study demonstrated for the first time that a specific diet significantly and positively affected neuroendocrine parameters and dROMs. These results open significant perspectives concerning the use of diet and nutraceuticals in the treatment of behavioural disorders.

Keywords: Neuroendocrine parameters; anxiety; behavioral disorders; chronic stress; nutraceutical diet; stress parameters.

FIG 1:

Graphical representation of serum neurotransmitters concentration of dogs belonging to control diet (CD) and nutraceutical diet (ND) groups before (T0) and after 45 days (T1) of diet supplementation. (a) Serotonin, (b) dopamine, (c) noradrenaline, (d) cortisol and (e) β-endorphins.

FIG 2:

Graphical representation of serum oxidative stress parameters concentration of dogs. belonging to control diet (CD) and nutraceutical diet (ND) groups before (T0) and after 45 days (T1) of diet supplementation. (a) derivatives of reactive oxygen metabolites (dROMs) values and (b) biological antioxidant potential (BAP).