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Review
. 2017 Jan;17(1):65-74.
doi: 10.1038/nrc.2016.113. Epub 2016 Nov 25.

The disparate origins of ovarian cancers: pathogenesis and prevention strategies

Anthony N Karnezis  1 , Kathleen R Cho  2 , C Blake Gilks  1 , Celeste Leigh Pearce  3 , David G Huntsman  1
Affiliations
Review

The disparate origins of ovarian cancers: pathogenesis and prevention strategies

Anthony N Karnezis et al. Nat Rev Cancer. 2017 Jan.

Abstract

Ovarian cancer is the fifth cause of cancer-related death in women and comprises a histologically and genetically broad range of tumours, including those of epithelial, sex cord-stromal and germ cell origin. Recent evidence indicates that high-grade serous ovarian carcinoma, clear cell carcinoma and endometrioid carcinoma primarily arise from tissues that are not normally present in the ovary. These histogenetic pathways are informing risk-reduction strategies for the prevention of ovarian and ovary-associated cancers and have highlighted the importance of the seemingly unique ovarian microenvironment.

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