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. 2017 Mar;162(3):857-861.
doi: 10.1007/s00705-016-3167-2. Epub 2016 Nov 24.

Expression of human endogenous retrovirus K and W in babies

L H S Nali  1 , A C S Oliveira  1 , D O Alves  1 , G S Caleiro  1 , C F Nunes  1 , D Gerhardt  1   2 , R C M Succi  2 , Camila M Romano  3 , D M Machado  1   2
Affiliations

Expression of human endogenous retrovirus K and W in babies

L H S Nali et al. Arch Virol. 2017 Mar.

Abstract

Here we determined the relative expression of HERV-K and W proviruses in HIV infected and non-infected mothers as well as their respective babies up to 1 year-old. HIV-infected mothers, their babies and uninfected control groups presented expression of both HERV-K and HERV-W with relatively high frequency. While the level of HERV-K expression was similar among groups, the level of HERV-W expression in HIV-infected mothers was four-fold higher than the uninfected mothers from the control group (p < 0.01). HERV-W was down regulated in HIV-exposed babies in comparison to non-exposed babies. To our knowledge, this is the first report of HERV transcriptional activity in babies from 0-1 year-old.

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