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. 2016 Dec;11(8):767-775.
doi: 10.2217/rme-2016-0111. Epub 2016 Nov 25.

Regenerative Medicine: lessons from Mother Nature

Juan Diego Naranjo  1   2 , Michelle E Scarritt  1   2 , Luai Huleihel  1   2 , Anjani Ravindra  1   3 , Crisanto M Torres  1   2 , Stephen F Badylak  1   2   4
Affiliations

Regenerative Medicine: lessons from Mother Nature

Juan Diego Naranjo et al. Regen Med. 2016 Dec.

Abstract

Regenerative medicine strategies for the restoration of functional tissue have evolved from the concept of ex vivo creation of engineered tissue toward the broader concept of in vivo induction of functional tissue reconstruction. Multidisciplinary approaches are being investigated to achieve this goal using evolutionarily conserved principles of stem cell biology, developmental biology and immunology, current methods of engineering and medicine. This evolution from ex vivo tissue engineering to the manipulation of fundamental in vivo tenets of development and regeneration has the potential to capitalize upon the incredibly complex and only partially understood ability of cells to adapt, proliferate, self-organize and differentiate into functional tissue.

Keywords: bioscaffolds; blastema; constructive remodeling; development; microenvironmental niche; regeneration; stem cell; tissue engineering; whole-organ engineering.

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Conflict of interest statement

Financial & competing interests disclosure

The authors have no relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript. This includes employment, consultancies, honoraria, stock ownership or options, expert testimony, grants or patents received or pending, or royalties.

No writing assistance was utilized in the production of this manuscript.

Figures

<b>Figure 1.</b>
Figure 1.. Visual representation of the wound healing response.
The events that comprise wound healing involve the presence of different cell types at the site of injury. Coagulation occurs rapidly as platelets cluster to seal injured vasculature. Inflammation is marked by early neutrophil infiltration followed by macrophage infiltration. Neutrophil participation dissipates early while fibroblasts and macrophages persist during the maturation of the resulting scar. Adapted from [13].
See this image and copyright information in PMC

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