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. 2017 Jan;24(1):1-2.
doi: 10.1038/cdd.2016.137. Epub 2016 Nov 25.

Fumarate drives EMT in renal cancer

Marco Sciacovelli  1 , Christian Frezza  1
Affiliations

Fumarate drives EMT in renal cancer

Marco Sciacovelli et al. Cell Death Differ. 2017 Jan.
No abstract available

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Figures

Figure 1
Figure 1
Schematic representation of the proposed link between FH loss and EMT activation. Left panel: In epithelial Fh1-proficient cells, TETs bind the mir-200 regulatory region, favouring DNA demethylation and miR-200 expression. miR-200 can then bind its mRNA targets such as Zeb1, efficiently reducing Zeb1 translation. Right panel: After FH loss, fumarate is accumulated and inhibits TETs activity, leading to mir-200 DNA hypermethylation. The reduced expression of miR-200 favours Zeb1 translation and subsequent EMT reprogramming. Cells switch their phenotype, moving from an epithelial to a mesenchymal configuration
See this image and copyright information in PMC

References

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