Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2017 Jan;24(1):1-2.
doi: 10.1038/cdd.2016.137. Epub 2016 Nov 25.

Fumarate drives EMT in renal cancer

Marco Sciacovelli  1 , Christian Frezza  1
Affiliations

Fumarate drives EMT in renal cancer

Marco Sciacovelli et al. Cell Death Differ. 2017 Jan.
No abstract available

PubMed Disclaimer

Figures

Figure 1
Figure 1
Schematic representation of the proposed link between FH loss and EMT activation. Left panel: In epithelial Fh1-proficient cells, TETs bind the mir-200 regulatory region, favouring DNA demethylation and miR-200 expression. miR-200 can then bind its mRNA targets such as Zeb1, efficiently reducing Zeb1 translation. Right panel: After FH loss, fumarate is accumulated and inhibits TETs activity, leading to mir-200 DNA hypermethylation. The reduced expression of miR-200 favours Zeb1 translation and subsequent EMT reprogramming. Cells switch their phenotype, moving from an epithelial to a mesenchymal configuration
See this image and copyright information in PMC

References

    1. Sciacovelli M, Frezza C. Free Radic Biol Med 2016. (this issue). - PMC - PubMed
    1. Tomlinson IP et al. Nat Genet 2002; 30: 406–410. - PubMed
    1. Frezza C et al. Nature 2011; 477: 225–228. - PubMed
    1. Pollard PJ et al. Hum Mol Genet 2005; 14: 2231–2239. - PubMed
    1. Xiao M et al. Genes Dev 2012; 26: 1326–1338. - PMC - PubMed