Itch in Atopic Dermatitis
- PMID: 27886901
- DOI: 10.1016/j.iac.2016.08.007
Itch in Atopic Dermatitis
Abstract
Chronic itch in inflammatory skin diseases, such as atopic dermatitis, markedly diminishes the quality of life of affected individuals. Comprehensive progress has been made in understanding itch signaling and associated mediators in the skin, dorsal root ganglia, spinal cord, and central nervous system, which may amplify or suppress atopic itch. Conventional therapies for atopic dermatitis are capable of reducing atopic itch; however, most patients are not satisfied with the antipruritic capacity of conventional treatments. Exploring itch pathways and mechanisms may lead to novel therapeutic approaches for atopic itch.
Keywords: Atopic dermatitis; Hypersensitivity of pruritus; New therapy; Pruritogen; Pruritus.
Copyright © 2016 Elsevier Inc. All rights reserved.
Similar articles
-
New therapies for controlling atopic itch.J Dermatol. 2015 Sep;42(9):847-50. doi: 10.1111/1346-8138.13060. J Dermatol. 2015. PMID: 26332459 Review.
-
Management of Itch in Atopic Dermatitis.Am J Clin Dermatol. 2018 Jun;19(3):319-332. doi: 10.1007/s40257-017-0335-4. Am J Clin Dermatol. 2018. PMID: 29285724 Review.
-
What causes itch in atopic dermatitis?Curr Allergy Asthma Rep. 2008 Jul;8(4):306-11. doi: 10.1007/s11882-008-0049-z. Curr Allergy Asthma Rep. 2008. PMID: 18606082 Review.
-
Neuroimmune interactions in chronic itch of atopic dermatitis.J Eur Acad Dermatol Venereol. 2020 Feb;34(2):239-250. doi: 10.1111/jdv.15973. Epub 2019 Nov 12. J Eur Acad Dermatol Venereol. 2020. PMID: 31566796 Free PMC article. Review.
-
Pathophysiology and therapy of pruritus in allergic and atopic diseases.Allergy. 2010 Jul;65(7):805-21. doi: 10.1111/j.1398-9995.2010.01995.x. Epub 2010 Apr 7. Allergy. 2010. PMID: 20384615 Review.
Cited by
-
Cholesterol Nanofiber Patches with Sustainable Oil Delivery Eliminate Inflammation in Atopic Skin.ACS Appl Mater Interfaces. 2024 Jul 24;16(29):37783-37794. doi: 10.1021/acsami.4c09400. Epub 2024 Jul 12. ACS Appl Mater Interfaces. 2024. PMID: 38994590 Free PMC article.
-
OX40-OX40L Inhibition for the Treatment of Atopic Dermatitis-Focus on Rocatinlimab and Amlitelimab.Pharmaceutics. 2022 Dec 8;14(12):2753. doi: 10.3390/pharmaceutics14122753. Pharmaceutics. 2022. PMID: 36559247 Free PMC article. Review.
-
Scratching Counteracts IL-13 Signaling by Upregulating the Decoy Receptor IL-13Rα2 in Keratinocytes.Int J Mol Sci. 2019 Jul 6;20(13):3324. doi: 10.3390/ijms20133324. Int J Mol Sci. 2019. PMID: 31284553 Free PMC article.
-
Paediatric Atopic Dermatitis: The Unexpected Impact on Life with a Specific Look at the Molecular Level.Int J Mol Sci. 2024 Apr 27;25(9):4778. doi: 10.3390/ijms25094778. Int J Mol Sci. 2024. PMID: 38731996 Free PMC article. Review.
-
Study on the molecular mechanism of atopic dermatitis in mice based on skin and serum metabolomic analysis.Metabolomics. 2024 Nov 13;20(6):131. doi: 10.1007/s11306-024-02196-x. Metabolomics. 2024. PMID: 39537935
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
Medical
Research Materials