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Review
. 2017 Feb;37(1):153-164.
doi: 10.1016/j.iac.2016.08.017. Epub 2016 Oct 28.

Mastocytosis and Anaphylaxis

Anna Schuch  1 , Knut Brockow  2
Affiliations
Review

Mastocytosis and Anaphylaxis

Anna Schuch et al. Immunol Allergy Clin North Am. 2017 Feb.

Abstract

This article updates current knowledge on epidemiology, risk factors, triggers, and management of anaphylaxis in patients with mastocytosis. Hyperactive mast cells and higher number of effector mast cells are speculated to facilitate anaphylaxis in this condition. In children, increased risk is limited to those with extensive skin involvement and high tryptase. In adults, manifestations of anaphylaxis are severe with high frequency of cardiovascular symptoms. Hymenoptera stings are the most common triggers for these reactions; however, idiopathic anaphylaxis and reactions to food or drugs occur. Patients with mastocytosis should be informed about risk of anaphylaxis and prescribing emergency self-medication and installing emergency preparedness before general anesthesia is considered.

Keywords: Anaphylaxis; Drug-induced anaphylaxis; Hymenoptera venom anaphylaxis; Mast cell activation syndrome; Mastocytosis; Risk factors; Triggers.

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