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Review
. 2017 Jun:64:57-64.
doi: 10.1016/j.ceca.2016.11.003. Epub 2016 Nov 17.

Probes for manipulating and monitoring IP3

Akitoshi Miyamoto  1 , Katsuhiko Mikoshiba  2
Affiliations
Review

Probes for manipulating and monitoring IP3

Akitoshi Miyamoto et al. Cell Calcium. 2017 Jun.

Abstract

Inositol 1,4,5-trisphosphate (IP3) is an important second messenger produced via G-protein-coupled receptor- or receptor tyrosine kinase-mediated pathways. IP3 levels induce Ca2+ release from the endoplasmic reticulum (ER) via IP3 receptor (IP3R) located in the ER membrane. The resultant spatiotemporal pattern of Ca2+ signals regulates diverse cellular functions, including fertilization, gene expression, synaptic plasticity, and cell death. Therefore, monitoring and manipulating IP3 levels is important to elucidate not only the functions of IP3-mediated pathways but also the encoding mechanism of IP3R as a converter of intracellular signals from IP3 to Ca2+.

Keywords: IP(3) induced Ca(2+) response; IP(3) probes.

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