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Review
. 2016 Dec;30(6):1317-1332.
doi: 10.1016/j.hoc.2016.07.012.

Transformed Lymphoma

Mary Ann Anderson  1 , Piers Blombery  2 , John F Seymour  3
Affiliations
Review

Transformed Lymphoma

Mary Ann Anderson et al. Hematol Oncol Clin North Am. 2016 Dec.

Abstract

Transformed lymphoma is a complex syndrome that encompasses an array of different underlying low-grade lymphoproliferative conditions transforming into more aggressive disease as manifest by morphologic, clinical, and genetic features. Over the last decade, advances in chemoimmunotherapy have led to new options. Knowledge surrounding the genetic changes driving the process of transformation is leading to novel targeted therapies. This article focuses on the transformation of chronic lymphocytic leukemia and follicular lymphoma into diffuse large B-cell lymphoma.

Keywords: Genetic drivers; Indolent lymphoma; Transformed lymphoma.

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