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. 2017 Feb:134:114-121.
doi: 10.1016/j.phytochem.2016.11.011. Epub 2016 Nov 23.

Selagintriflavonoids with BACE1 inhibitory activity from the fern Selaginella doederleinii

Zhenxing Zou  1 , Pingsheng Xu  2 , Guogang Zhang  2 , Fei Cheng  3 , Kai Chen  4 , Jing Li  3 , Weixing Zhu  3 , Dongsheng Cao  3 , Kangping Xu  5 , Guishan Tan  6
Affiliations

Selagintriflavonoids with BACE1 inhibitory activity from the fern Selaginella doederleinii

Zhenxing Zou et al. Phytochemistry. 2017 Feb.

Abstract

Eight triflavonoids, selagintriflavonoids A-H, were isolated from whole herbs of Selaginella doederleinii. The structures of compounds selagintriflavonoids A-C consisted of three naringenin units, whereas those of selagintriflavonoids D-H consisted of apigenin and two naringenin moieties. The structures and absolute configurations of the compounds were determined based on NMR, HRESIMS, and experimental and calculated electronic circular dichroism (ECD) data. The ability of the compounds to inhibit β-secretase (BACE1) was also evaluated. All compounds exhibited BACE1 inhibition with IC50 values ranging from 0.75 to 46.99 μM. Selagintriflavonoid A exhibited the strongest inhibition (0.75 μM) and is thus a promising compound for treating Alzheimer's disease.

Keywords: Absolute configuration; BACE1; Selaginella; Selaginella doederleinii; Selaginellaceae; Triflavonoids.

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