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. 2017 Jan:274:65-72.
doi: 10.1016/j.jmr.2016.11.008. Epub 2016 Nov 18.

Large dose hyperpolarized water with dissolution-DNP at high magnetic field

Kasper Wigh Lipsø  1 , Sean Bowen  1 , Oleksandr Rybalko  1 , Jan Henrik Ardenkjær-Larsen  2
Affiliations

Large dose hyperpolarized water with dissolution-DNP at high magnetic field

Kasper Wigh Lipsø et al. J Magn Reson. 2017 Jan.

Abstract

We demonstrate a method for the preparation of hyperpolarized water by dissolution Dynamic Nuclear Polarization at high magnetic field. Protons were polarized at 6.7T and 1.1K to >70% with frequency modulated microwave irradiation at 188GHz. 97.2±0.7% of the radical was extracted from the sample in the dissolution in a two-phase system. 16±1mL of 5.0M 1H in D2O with a polarization of 13.0±0.9% in the liquid state was obtained, corresponding to an enhancement factor of 4000±300 compared to the thermal equilibrium at 9.4T and 293K. A longitudinal relaxation time constant of 16±1s was measured. The sample was polarized and dissolved in a fluid path compatible with clinical polarizers. The volume of hyperpolarized water produced by this method enables angiography and perfusion measurements in large animals, as well as NMR experiments for studies of e.g. proton exchange and polarization transfer to other nuclei.

Keywords: Dissolution-DNP; Hyperpolarization; Hyperpolarized water.

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