Imaging of Perineural Spread in Head and Neck Cancer

Abstract

Perineural spread (PNS) of tumor is a recognized pattern of metastasis occurring in the head and neck. Imaging plays a critical role in identifying PNS for adequate staging and treatment planning. Understanding the major branches and pathways of cranial nerves V and VII, key anatomic landmarks, interconnections between these nerves, and pearls and pitfalls of PNS imaging can aid in early detection, appropriate therapy, and the best possible chance for cure.

Keywords: Head and neck cancer; Perineural invasion; Perineural spread; Skull base imaging.