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Review
. 2016 Dec;29(4):341-344.
doi: 10.1016/j.beha.2016.10.008. Epub 2016 Oct 20.

Is there justification for 4 cycles of consolidation therapy in AML?

Richard F Schlenk  1
Affiliations
Review

Is there justification for 4 cycles of consolidation therapy in AML?

Richard F Schlenk. Best Pract Res Clin Haematol. 2016 Dec.

Abstract

The concept of postremission therapy in acute myeloid leukemia is quite old, dating back to a trial conducted in 1988 by the Cancer and Leukemia Group B. Yet even with more than 20 years of investigation into the optimal number of cycles for consolidation therapy, the answer is still not entirely clear. Dose intensity also has an impact on the number of courses of consolidation therapy administered, as do the cytogenetics of the patients. This review examines how to direct the future of consolidation therapy outside of allogeneic transplantation and discusses the issues to consider in choosing the number of courses of consolidation, including the effect minimal residual disease may have in guiding decisions regarding consolidation treatment.

Keywords: AML; Acute myeloid leukemia; CBF; Consolidation; Core binding factor; Genetic landscape; MRD; Minimal residual disease; Mutation status; NPM1; Nucleophosmin 1.

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