Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2016:2016:5016840.
doi: 10.1155/2016/5016840. Epub 2016 Nov 7.

Primary Diffuse Leptomeningeal Gliomatosis: Radiological/Pathological Features

Ehtasham Ahmad  1 , Mohamed Mohamed  1 , Apostolos Vrettos  2
Affiliations

Primary Diffuse Leptomeningeal Gliomatosis: Radiological/Pathological Features

Ehtasham Ahmad et al. Case Rep Neurol Med. 2016.

Abstract

We present the case of a 43-year-old lady who presented with headaches, visual impairment, and seizures, progressing rapidly over the course of a few weeks. Extensive workup excluded an inflammatory or infectious cause. Imaging studies revealed diffuse thickening of the leptomeninges and serial CSF analysis showed raised opening pressures and increased protein levels. A diagnostic biopsy of the lower thoracic dura confirmed the diagnosis of primary diffuse leptomeningeal gliomatosis (PDGL). She was managed supportively for her symptoms and unfortunately she passed away a few weeks later.

PubMed Disclaimer

Conflict of interest statement

The authors declare that there are no competing interests regarding the publication of this paper.

Figures

Figure 1
Figure 1
Axial head CT.
Figure 2
Figure 2
Axial head MRI.
Figure 3
Figure 3
Sagittal head MRI.
Figure 4
Figure 4
Spine MRI, thoracic region.
Figure 5
Figure 5
Spine MRI, lumbosacral region.
Figure 6
Figure 6
The biopsy from the lower thoracic dura showed fibrous tissue lined by meningothelial type of cells with nests of moderately pleomorphic cells. These cells appeared fibrillary, rounded, and occasionally gemistocytic or multinucleated. Proliferating vascular clusters were present as well. Occasional round cells were seen forming clusters in plane.
See this image and copyright information in PMC

References

    1. Ruiz-Ares G., Collantes-Bellido E., Rodriguez De Rivera F., et al. Primary diffuse leptomeningeal gliomatosis mimicking meningeal tuberculosis. Neurologist. 2011;17(3):160–163. doi: 10.1097/NRL.0b013e3182173510. - DOI - PubMed
    1. Bilic M., Welsh C. T., Rumboldt Z., Hoda R. S. Disseminated primary diffuse leptomeningeal gliomatosis: a case report with liquid based and conventional smear cytology. CytoJournal. 2005;2, article 16 doi: 10.1186/1742-6413-2-16. - DOI - PMC - PubMed
    1. Jabeen S. A., Chowdary A. H., Kandadai R. M., et al. Primary diffuse leptomeningeal gliomatosis: an autopsy case report. Annals of Indian Academy of Neurology. 2014;17(2):227–230. doi: 10.4103/0972-2327.132647. - DOI - PMC - PubMed
    1. Debono B., Derrey S., Rabehenoina C., Proust F., Freger P., Laquerrière A. Primary diffuse multinodular leptomeningeal gliomatosis: case report and review of the literature. Surgical Neurology. 2006;65(3):273–282. doi: 10.1016/j.surneu.2005.06.038. - DOI - PubMed
    1. Dietrich P.-Y., Aapro M. S., Rieder A., Pizzolato G. R. Primary diffuse leptomeningeal gliomatosis (PDLG): a neoplastic cause of chronic meningitis. Journal of Neuro-Oncology. 1993;15(3):275–283. doi: 10.1007/bf01050075. - DOI - PubMed

LinkOut - more resources