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Case Reports
. 2016 Oct;10(10):XD01-XD02.
doi: 10.7860/JCDR/2016/21396.8614. Epub 2016 Oct 1.

Paclitaxel Induced Acute ST Elevation Myocardial Infarction: A Rare Case Report

Gautam Rawal  1 , Sankalp Yadav  2 , Raj Kumar  3
Affiliations
Case Reports

Paclitaxel Induced Acute ST Elevation Myocardial Infarction: A Rare Case Report

Gautam Rawal et al. J Clin Diagn Res. 2016 Oct.

Abstract

Paclitaxel, is a frequently used anti-neoplastic agent and is included in various chemotherapy regimens. The life threatening cardio toxicity associated with its use and the still unclear pathophysiology, has limited the use of this drug. Acute myocardial infarction is a rare adverse event associated with this drug. We report a case of acute ST-elevation myocardial infarction induced by paclitaxel infusion in a patient of oesophageal carcinoma who was saved by percutaneous primary intervention. The authors emphasize the awareness of this side effect of Paclitaxel among the clinicians.

Keywords: Bradyarrhythmia; Chemotherapy; Coronary thrombosis; Oesophageal carcinoma; Taxol.

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Figures

[Table/Fig-1]:
[Table/Fig-1]:
ECG showing ST elevation in the inferior leads (lead II, III and aVF), bradycardia (HR 40/min) with junctional escape rhythm s/o acute inferior wall myocardial infarction (AIWMI).
[Table/Fig-2a,b]:
[Table/Fig-2a,b]:
(a) Coronary angiography revealing 100% stenosis of proximal RCA (arrow); (b) Post PTCA with stent placement in RCA showing normal flow (arrow).
[Table/Fig-3]:
[Table/Fig-3]:
ECG post PTCA showing reversal of ST changes and normal sinus rhythm.
See this image and copyright information in PMC

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