Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2016 Oct;10(10):ZC51-ZC54.
doi: 10.7860/JCDR/2016/18991.8649. Epub 2016 Oct 1.

An In-vitro Comparison of Nano Hydroxyapatite, Novamin and Proargin Desensitizing Toothpastes - A SEM Study

Rithesh Kulal  1 , Ipsita Jayanti  2 , Savita Sambashivaiah  3 , Shivaprasad Bilchodmath  1
Affiliations

An In-vitro Comparison of Nano Hydroxyapatite, Novamin and Proargin Desensitizing Toothpastes - A SEM Study

Rithesh Kulal et al. J Clin Diagn Res. 2016 Oct.

Abstract

Introduction: Dentinal Hypersensitivity (DH) is commonly encountered clinical condition in dental practice which affects 8-57% of the adult population presenting for dental treatment, but the treatment of the same remains doubtful.

Aim: The purpose of this study was to evaluate and compare the effects of three different desensitizing agents (15% nano hydroxyapatite crystals; 5% novamin and 8% proargin) on dentinal permeability and tubule occlusion in-vitro. Scanning Electron Microscope (SEM) was used to evaluate the effect of these commercially available desensitizing toothpastes.

Materials and methods: A total of 40 disc shaped dentin specimens were dissected from extracted premolars. Dentin discs of 1mm were obtained with the help of diamond discs. Ten specimens were randomly selected and allocated to the evaluation groups A (control group), B (Nano-hydroxyapatite), C (Novamin) and D (Proargin). Each treatment group dentine disc specimen was treated with the respective slurry for two minutes for a period of seven days. Each disc was subjected to a pre- and post-treatment SEM analysis to evaluate the changes occurring in the dentinal tubules.

Results: The qualitative analysis showed no occlusion of the dentinal tubules in Group A (control group) and Group B (nano-hydroxyapatite) showed 98.1% tubule occlusion. Group C (Novamin) and D (Proargin) showed 83.1% and 69.1% tubule occlusion respectively. Quantitative analysis showed a statistical significant difference between Group B and D (p< 0.005) and no statistical significant difference between group B and C (p= 0.235). Similarly, there was no significant difference between Group C and D as (p=0.235).

Conclusion: It was concluded that all the three desensiting agents were effective in the dentine tubule occlusion. In addition efficacy of nano-hydroxyapatite toothpaste was greater compared to the other desensiting agents.

Keywords: Bioactive glass; Biomaterials; Dentin disc; Dentin hypersensitivity.

PubMed Disclaimer

Figures

[Table/Fig-4a,b]:
[Table/Fig-4a,b]:
(a) Pre-treatment SEM picture of group A; (b) Post-treatment SEM picture of group A.
[Table/Fig-5a,b]:
[Table/Fig-5a,b]:
(a) Pre-treatment SEM picture of group B; (b) Post-treatment SEM picture of group B.
[Table/Fig-6a,b]:
[Table/Fig-6a,b]:
(a) Pre-treatment SEM picture of group C; (b) Post-treatment SEM picture of group C.
[Table/Fig-7a,b]:
[Table/Fig-7a,b]:
(a) Pre-treatment SEM picture of group D; (b) Post-treatment SEM picture of group D.
See this image and copyright information in PMC

References

    1. Walters PA. Dentinal hypersensitivity: A review. J Contemp Dent Pract. 2005;6:107–17. - PubMed
    1. Shetty S, Kohad R, Yeltiwar R. Hydroxyapatite as an in-office agent for tooth hypersensitivity: A clinical and scanning electron microscopic study. J Periodontol. 2010;81:1781–89. - PubMed
    1. Santiago SL, Pereira JC, Martineli AC. Effect of commercially available and experimental potassium oxalate-based dentin desensitizing agents in dentin permeability: Influence of time and filtration system. Braz Dent J. 2006;17:300–05. - PubMed
    1. Braennstroem M, Astroem A. A study on the mechanism of pain elicited from the dentin. Dent Res. 1964;43:619–25. - PubMed
    1. Porto IC, Andrade AK, Montes MA. Diagnosis and treatment of dentinal hypersensitivity. J Oral Sci. 2009;51(3):323–32. - PubMed