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. 2016 Oct 1;17(10):4735-4739.
doi: 10.22034/apjcp.2016.17.10.4735.

Patterns of Recurrence after Resection of Mass-Forming Type Intrahepatic Cholangiocarcinomas

Vor Luvira  1 , Chalerm Eurboonyanun, Vajarabhongsa Bhudhisawasdi, Ake Pugkhem, Chawalit Pairojkul, Varisara Luvira, Egapong Sathitkarnmanee, Kulyada Somsap, Supot Kamsa-ard
Affiliations

Patterns of Recurrence after Resection of Mass-Forming Type Intrahepatic Cholangiocarcinomas

Vor Luvira et al. Asian Pac J Cancer Prev. .

Abstract

Background: Intrahepatic cholangiocarcinoma (IHCCA) is an aggressive tumor for which surgical resection is a mainstay of treatment. However, recurrence after resection is common associated with a poor prognosis. Studies regarding recurrence of mass-forming IHCCA are rare; therefore, we investigated the pattern with our dataset. Methods: We retrospectively reviewed the medical and pathological records of 50 mass-forming IHCCA patients who underwent hepatic resection between January 2004 and December 2009 in order to determine the patterns of recurrence and prognosis. All demographic and operative parameters were analyzed for their effects on recurrence-free survival. Results: The median recurrence-free survival time was 188 days (95%CI: 149-299). The respective 1-, 2-, and 3-year recurrence-free survival rates were 16.2% (95%CI: 6.6-29.4), 5.4% (95%CI: 1.0-15.8) and 2.7% (95%CI: 0.2-12.0). There was an equal distribution of recurrence at solitary and multiple sites. Univariate analysis revealed no factors related to recurrence-free survival.Conclusion: The overall survival and recurrence-free survival after surgery for mass-forming IHCCA were found to be very poor. Almost all recurrences were detected within 2 years after surgery. Adjuvant chemotherapy after surgery may add benefit in the affected patients.

Keywords: Mass forming intrahepatic cholangiocarcinoma; recurrence; survival; curative resection.

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Figures

Figure 1
Figure 1
(a) Overall Survival and (b) Recurrence-Free Survival of Mass-Forming Intrahepatic Cholangiocarcinoma Patients Treated by Hepatic resection
Figure 2
Figure 2
Recurrence-Free Survival of Mass-Forming Intrahepatic Cholangiocarcinoma Patients Treated by Hepatic Resection Stratified by Status of Resection Margin
Figure 3
Figure 3
Recurrence-Free Survival of Mass-Forming Intrahepatic Cholangiocarcinoma Patients Treated by Hepatic Resection Stratified by Postoperative Treatment
Figure 4
Figure 4
Pattern of Recurrences (%) of Mass-Forming According to Side of Hepatic Resection: (a) Left-Sided Hepatectomy, and (b) Right-Sided Hepatectomy
See this image and copyright information in PMC

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