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Review
. 2017 Jan:86:5-13.
doi: 10.1016/j.jcv.2016.11.005. Epub 2016 Nov 11.

Ebola virus disease: An update on current prevention and management strategies

M A Trad  1 , W Naughton  2 , A Yeung  2 , L Mazlin  3 , M O'sullivan  4 , N Gilroy  5 , D A Fisher  6 , R L Stuart  7
Affiliations
Review

Ebola virus disease: An update on current prevention and management strategies

M A Trad et al. J Clin Virol. 2017 Jan.

Abstract

Ebola virus disease (EVD) is characterised by systemic viral replication, immuno-suppression, abnormal inflammatory responses, large volume fluid and electrolyte losses, and high mortality in under-resourced settings. There are various therapeutic strategies targeting EVD including vaccines utilizing different antigen delivery methods, antibody-based therapies and antiviral drugs. These therapies remain experimental, but received attention following their use particularly in cases treated outside West Africa during the 2014-15 outbreak, in which 20 (80%) out of 25 patients survived. Emerging data from current trials look promising and are undergoing further study, however optimised supportive care remains the key to reducing mortality from EVD.

Keywords: Ebola; Ebolavirus; Management; Outbreak; Therapeutics; Vaccines.

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