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Review
. 2017 Feb;64(1):27-37.
doi: 10.1016/j.pcl.2016.08.007.

Immunodeficiency Presenting as an Undiagnosed Disease

John M Routes  1 , James W Verbsky  2
Affiliations
Review

Immunodeficiency Presenting as an Undiagnosed Disease

John M Routes et al. Pediatr Clin North Am. 2017 Feb.

Abstract

Although primary immunodeficiencies typically present with recurrent, chronic, or severe infections, autoimmune manifestations frequently accompany these disorders and may be the initial clinical manifestations. The presence of 2 or more autoimmune disorders, unusual severe atopic disease, or a combination of these disorders should lead a clinician to consider primary immunodeficiency disorders.

Keywords: Autoimmunity; Common variable immunodeficiency; Granulomatous and lymphocytic interstitial lung disease; IPEX; Immune dysregulation, polyendocrinopathy, enteropathy, X-linked; Primary immunodeficiencies.

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