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. 2016 Nov;59(3):226-230.
doi: 10.3164/jcbn.16-43. Epub 2016 Aug 24.

Characteristics of gastric cancer detected within 1 year after successful eradication of Helicobacter pylori

Toshihiro Nishizawa  1 , Hidekazu Suzuki  2 , Toru Arano  3 , Shuntaro Yoshida  4 , Hiroharu Yamashita  5 , Keisuke Hata  6 , Takanori Kanai  7 , Naohisa Yahagi  8 , Osamu Toyoshima  9
Affiliations

Characteristics of gastric cancer detected within 1 year after successful eradication of Helicobacter pylori

Toshihiro Nishizawa et al. J Clin Biochem Nutr. 2016 Nov.

Abstract

Gastric cancers are sometimes diagnosed in patients who have successfully undergone Helicobacter pylori (H. pylori) eradication. We analyzed the clinicopathological features of gastric cancers detected after eradication to clarify their characteristics. We reviewed 31 patients with 34 cases of gastric cancer detected after successful H. pylori eradication. Clinicopathological characteristics analyzed included interval since eradication, interval since last endoscopy, tumor size, and depth of invasion. Patients were classified into two groups: early detection (<1 year since eradication) and delayed detection (≥1 year since eradication). The interval since last endoscopy was significantly shorter in the early detection group than in the delayed detection group. However, gastric cancers were significantly larger and more invasive in the early detection group than in the delayed detection group. In conclusion, diligent endoscopy is necessary during the first year after successful H. pylori eradication. (The University Hospital Medical Information Network clinical trial registration number is UMIN000018541.).

Keywords: H. pylori; eradication; gastric cancer.

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Conflict of interest statement

No potential conflicts of interest were disclosed.

Figures

Fig. 1
Fig. 1
Flow chart of the gastric tumors analyzed in this study. A total of 112 gastric cancers in 96 consecutive patients were reviewed. After exclusion criteria were applied, 34 gastric cancers detected after successful H. pylori eradication in 31 patients were further evaluated.
Fig. 2
Fig. 2
Scatter plot in between interval from eradication interval and tumor size. The median tumor sizes in the early and delayed detection groups were 17.5 and 8 mm, respectively.
Fig. 3
Fig. 3
Representative endoscopic images before and after eradication. (A, B) Before eradication, gastric cancer was not detected. (C, D) After eradication (11 months), gastric cancer was detected. The size was 33 mm, the depth of tumor invasion was muscularis propria, and the histology subtype was moderately-differentiated adenocarcinoma.
Fig. 4
Fig. 4
Representative endoscopic images before and after eradication. (A, B) Before eradication, gastric cancer was not detected. (C, D) After eradication (19 months), gastric cancer was detected. The size was 13 mm, the depth of tumor invasion was mucosa, and the histology subtype was well-differentiated adenocarcinoma.
See this image and copyright information in PMC

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