Allergy immunotherapy across the life cycle to promote active and healthy ageing: from research to policies: An AIRWAYS Integrated Care Pathways (ICPs) programme item (Action Plan B3 of the European Innovation Partnership on active and healthy ageing) and the Global Alliance against Chronic Respiratory Diseases (GARD), a World Health Organization GARD research demonstration project

M A Calderon¹, P Demoly², T Casale³, C A Akdis⁴, C Bachert⁵, M Bewick⁶, B M Bilò⁷, B Bohle⁸, S Bonini⁹, A Bush¹, D P Caimmi², G W Canonica¹⁰, V Cardona¹¹, A M Chiriac¹², L Cox¹³, A Custovic¹, F De Blay¹⁴, P Devillier¹⁵, A Didier¹⁶, G Di Lorenzo¹⁷, G Du Toit¹⁸, S R Durham¹⁹, P Eng²⁰, A Fiocchi²¹, A T Fox²², R Gerth van Wijk²³, R M Gomez²⁴, T Haathela²⁵, S Halken²⁶, P W Hellings²⁷, L Jacobsen²⁸, J Just²⁹, L K Tanno³⁰, J Kleine-Tebbe³¹, L Klimek³², E F Knol³³, P Kuna³⁴, D E Larenas-Linnemann³⁵, A Linneberg³⁶, M Matricardi³⁷, H J Malling³⁸, R Moesges³⁹, J Mullol⁴⁰, A Muraro⁴¹, N Papadopoulos⁴², G Passalacqua⁴³, E Pastorello⁴⁴, O Pfaar⁴⁵, D Price⁴⁶, P Rodriguez Del Rio⁴⁷, R Ruëff⁴⁸, B Samolinski⁴⁹, G K Scadding⁵⁰, G Senti⁵¹, M H Shamji⁵², A Sheikh⁵³, J C Sisul⁵⁴, D Sole⁵⁵, G J Sturm⁵⁶, A Tabar⁵⁷, R Van Ree⁵⁸, M T Ventura⁵⁹, C Vidal⁶⁰, E M Varga⁶¹, M Worm⁶², T Zuberbier⁶², J Bousquet⁶³

Affiliations

¹ National Heart and Lung Institute, Royal Brompton Hospital NHS, Imperial College London, London, UK.
² Unité d'allergologie, Département de Pneumologie et AddictologieHôpital Arnaud de Villeneuve, CHRU de Montpellier, Sorbonne Universités, UPMC Paris 06, UMR-S 1136, IPLESP, Equipe EPAR, 75013 Paris, France.
³ University of South Florida Morsani College of Medicine, Tampa, FL USA.
⁴ Christine Kühne Center for Allergy Research and Education (CK-CARE), Swiss Institute of Allergy and Asthma Research (SIAF)University of Zurich, Davos, Switzerland.
⁵ Upper Airways Research Laboratory (URL), ENT Department, University Hospital Ghent, Ghent, Belgium.
⁶ iQ4U consultants Ltd, London, UK.
⁷ Allergy Unit, Department of Internal Medicine, University Hosp Ospedali Riuniti, Ancona, Italy.
⁸ Department of Pathophysiology and Allergy Research, Center of Pathophysiology, Infectiology and Immunology, Medical University of Vienna, Vienna, Austria.
⁹ Second University of Naples and IFT-CNR, Rome, Italy.
¹⁰ Allergy and Respiratory Diseases Clinic, DIMI, University of Genoa, IRCCS AOU San Martino-IST, Genoa, Italy.
¹¹ Allergy Section, Department of Internal Medicine, Hospital Universitari Vall d'Hebron, Barcelona, Spain.
¹² Division of Allergy, Hôpital Arnaud de Villeneuve, Department of Pulmonology, University Hospital of Montpellier, Montpellier - UPMC Univ Paris 06, UMRS 1136, Equipe - EPAR - IPLESP, Sorbonne Universités, Paris, France.
¹³ Nova Southeastern University, Ft. Lauderdale, FL USA.
¹⁴ Allergy Division, Chest Disease Department, University Hospital of Strasbourg, Strasbourg, France.
¹⁵ University Versailles Saint-Quentin and Clinical Pharmacology Unit, UPRES EA 220, Department of Airway Diseases, Foch Hospital, Suresnes, France.
¹⁶ Respiratory Diseases Department, Rangueil-Larrey Hospital, Toulouse, France.
¹⁷ Dipartimento BioMedico di Medicina Interna e Specialistica (Di.Bi.M.I.S), University of Palermo, Palermo, Italy.
¹⁸ Guy's and St. Thomas' NHS Trust, Kings College, London, UK.
¹⁹ Allergy and Clinical Immunology Section, National Heart and Lung Institute, Imperial College London, London, UK.
²⁰ Department of Pediatric Pulmonology and Allergy, Children's Hospital, Aarau, Switzerland.
²¹ Division of Allergy, Department of Pediatrics, Bambino Gesù Pediatric Hospital, Vatican City, Rome, Italy.
²² King's College London Allergy Academy, London, UK.
²³ Section of Allergology, Department of Internal Medicine, Erasmus Medical Center, Building Rochussenstraat, Rotterdam, The Netherlands.
²⁴ Unidad Alergia and Asma, Hospital San Bernardo, Salta, Argentina.
²⁵ Skin and Allergy Hospital, Helsinki University Hospital, Helsinki, Finland.
²⁶ Hans Christian Andersen Children's Hospital, Odense University Hospital, Odense, Denmark.
²⁷ Clinical Department of Otorhinolaryngology, Head and Neck Surgery, University Hospitals Leuven, KU Leuven, Louvain, Belgium.
²⁸ Allergy Learning and Consulting, Secretary Immunotherapy Interest Group EAACI, Copenhagen, Denmark.
²⁹ Allergology Department, Centre de l'Asthme et des Allergies, Hôpital d'Enfants Armand-Trousseau, INSERM, UMR_S 1136, Sorbonne Universités, UPMC Univ Paris, Institut Pierre Louis d'Epidémiologie et de Santé Publique, Equipe EPAR, Paris, France.
³⁰ Hospital Sírio Libanês, São Paulo, Brazil ; University Hospital of Montpellier, Montpellier, France ; UPMC Paris 06, UMR-S 1136, IPLESP, Equipe EPAR, Sorbonne Universités, Paris, France.
³¹ Allergy and Asthma Center Westend, Outpatient Clinic and Clinical Research Center, Ackermann, Hanf, & Kleine-Tebbe, Berlin, Germany.
³² Center for Rhinology and Allergology, German Society for Otorhinolaryngology HNS, Wiesbaden, Germany.
³³ Departments of Immunology and Dermatology/Allergology, University Medical Center Utrecht, Heidelberglaan, Utrecht, The Netherlands.
³⁴ Medical University of Lodz, Lodz, Poland.
³⁵ ARIA, Mexico, DF Mexico ; AAAAI, Hospital Médica Sur, Mexico, DF Mexico.
³⁶ Research Centre for Prevention and Health, The Capital Region of Denmark, Copenhagen, Denmark ; Department of Clinical Experimental Research, Rigshospitalet, Copenhagen, Denmark ; Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
³⁷ Pediatric Pneumology and Immunology, Charité Medical University, Berlin, Germany.
³⁸ Danish Allergy Centre, Allergy Clinic, Gentofte University Hospital, Hellerup, Denmark.
³⁹ IMSIE, Klinikum der Universität zu Köln A. ö. R., Cologne, Germany.
⁴⁰ Unitat de Rinologia i Clínica de l'Olfacte, ENT Department, Hospital Clínic, Clinical and Experimental Respiratory Immunoallergy, IDIBAPS, CIBERES, Barcelona, Catalonia Spain.
⁴¹ Department of Women and Child Health, Food Allergy Referral Centre Veneto Region, Padua General University Hospital, Padua, Italy.
⁴² Allergy Unit, 2nd Pediatric Clinic, University of Athens, Athens, Greece.
⁴³ Allergy and Respiratory Diseases, IRCCS San Martino-IST, Univesity of Genoa, Genoa, Italy.
⁴⁴ ASST Grande Ospedale Metropolitano Niguarda, P.zza Ospedale Maggiore, Milan, Italy.
⁴⁵ Department of Otorhinolaryngology, Head and Neck Surgery, Universitätsmedizin Mannheim, Mannheim, Germany ; Medical Faculty Mannheim, Heidelberg University, Heidelberg, Germany ; Center for Rhinology and Allergology, Wiesbaden, Germany.
⁴⁶ Division of Applied Health Sciences, Primary Care Respiratory Medicine, Academic Primary Care, University of Aberdeen, Aberdeen, Scotland, UK ; Research in Real Life (RiRL), Oakington, Cambridge, UK ; Optimum Patient Care Ltd, Singapore, Singapore.
⁴⁷ Allergy Section, Hospital Infantil Universitario Niño Jesús, Madrid, Spain.
⁴⁸ Department of Dermatology and Allergology, Ludwig-Maximillian University, Munich, Germany.
⁴⁹ Department of Prevention of Environmental Hazards and Allergology, Medical University of Warsaw, Warsaw, Poland.
⁵⁰ Royal National Throat, Nose and Ear Hospital, London, UK ; University College London, London, UK.
⁵¹ Clinical Trials Center, University Hospital of Zurich, Zurich, Switzerland.
⁵² Immunomodulation and Tolerance Group, Allergy and Clinical Immunology, Inflammation, Repair and Development Section, National Heart and Lung Institute, Faculty of Medicine, Imperial College London, London, UK ; MRC and Asthma UK Centre in Allergic Mechanisms of Asthma, London, UK.
⁵³ Asthma UK Centre for Applied Research, Centre for Medical Informatics, Usher Institute of Population Health Sciences and Informatics, The University of Edinburgh, Teviot Place, Edinburgh, EH8 9AG UK.
⁵⁴ SLAAI, Asuncion, Paraguay.
⁵⁵ Programa de Pòs-Graduação em Pediatria e Ciências Aplicadas à Pediatria, Departamento de Pediatria EPM, UNIFESP, São Paulo, Brazil.
⁵⁶ Department of Dermatology and Venerology, Medical University of Graz, Graz, Austria ; Allergy Outpatient Clinic Reumannplatz, Vienna, Austria.
⁵⁷ Servicio de Alergologia, Complejo Hospitalario de Navarra, Pamplona, Spain.
⁵⁸ Departments of Experimental Immunology and Otorhinolaryngology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands.
⁵⁹ Unit of Geriatric Immunoallergology, Interdisciplinary Department of Medicine, University of Bari Medical School, Bari, Italy.
⁶⁰ Allergy Department, Complejo Hospitalario Universitario de Santiago de Compostela, Santiago de Compostela, Spain.
⁶¹ Respiratory and Allergic Disease Division, Department of Paediatrics, Medical University of Graz, Graz, Austria.
⁶² Allergie-Centrum-Charité, Klinik für Dermatologie, Venerologie und Allergologie, Charité-Universitätsmedizin Berlin, Berlin, Germany.
⁶³ University Hospital of Montpellier, Montpellier, France ; Contre les MAladies Chroniques pour un VIeillissement Actif en Languedoc-Roussillon, European Innovation Partnership on Active and Healthy Ageing Reference Site, Paris, France ; INSERM, VIMA, U1168, Ageing and Chronic Diseases, Epidemiological and Public Health Approaches, Paris, France ; UVSQ, UMR-S 1168, Université Versailles St-Quentin-en-Yvelines, Versailles Cedex, France ; CHRU, 371 Avenue du Doyen Gaston Giraud, 34295 Montpellier Cedex 5, France.

PMID: 27895895
PMCID: PMC5120439
DOI: 10.1186/s13601-016-0131-x

Review

Allergy immunotherapy across the life cycle to promote active and healthy ageing: from research to policies: An AIRWAYS Integrated Care Pathways (ICPs) programme item (Action Plan B3 of the European Innovation Partnership on active and healthy ageing) and the Global Alliance against Chronic Respiratory Diseases (GARD), a World Health Organization GARD research demonstration project

M A Calderon et al. Clin Transl Allergy. 2016.

. 2016 Nov 23:6:41.

doi: 10.1186/s13601-016-0131-x. eCollection 2016.

Authors

Affiliations

¹ National Heart and Lung Institute, Royal Brompton Hospital NHS, Imperial College London, London, UK.
² Unité d'allergologie, Département de Pneumologie et AddictologieHôpital Arnaud de Villeneuve, CHRU de Montpellier, Sorbonne Universités, UPMC Paris 06, UMR-S 1136, IPLESP, Equipe EPAR, 75013 Paris, France.
³ University of South Florida Morsani College of Medicine, Tampa, FL USA.
⁴ Christine Kühne Center for Allergy Research and Education (CK-CARE), Swiss Institute of Allergy and Asthma Research (SIAF)University of Zurich, Davos, Switzerland.
⁵ Upper Airways Research Laboratory (URL), ENT Department, University Hospital Ghent, Ghent, Belgium.
⁶ iQ4U consultants Ltd, London, UK.
⁷ Allergy Unit, Department of Internal Medicine, University Hosp Ospedali Riuniti, Ancona, Italy.
⁸ Department of Pathophysiology and Allergy Research, Center of Pathophysiology, Infectiology and Immunology, Medical University of Vienna, Vienna, Austria.
⁹ Second University of Naples and IFT-CNR, Rome, Italy.
¹⁰ Allergy and Respiratory Diseases Clinic, DIMI, University of Genoa, IRCCS AOU San Martino-IST, Genoa, Italy.
¹¹ Allergy Section, Department of Internal Medicine, Hospital Universitari Vall d'Hebron, Barcelona, Spain.
¹² Division of Allergy, Hôpital Arnaud de Villeneuve, Department of Pulmonology, University Hospital of Montpellier, Montpellier - UPMC Univ Paris 06, UMRS 1136, Equipe - EPAR - IPLESP, Sorbonne Universités, Paris, France.
¹³ Nova Southeastern University, Ft. Lauderdale, FL USA.
¹⁴ Allergy Division, Chest Disease Department, University Hospital of Strasbourg, Strasbourg, France.
¹⁵ University Versailles Saint-Quentin and Clinical Pharmacology Unit, UPRES EA 220, Department of Airway Diseases, Foch Hospital, Suresnes, France.
¹⁶ Respiratory Diseases Department, Rangueil-Larrey Hospital, Toulouse, France.
¹⁷ Dipartimento BioMedico di Medicina Interna e Specialistica (Di.Bi.M.I.S), University of Palermo, Palermo, Italy.
¹⁸ Guy's and St. Thomas' NHS Trust, Kings College, London, UK.
¹⁹ Allergy and Clinical Immunology Section, National Heart and Lung Institute, Imperial College London, London, UK.
²⁰ Department of Pediatric Pulmonology and Allergy, Children's Hospital, Aarau, Switzerland.
²¹ Division of Allergy, Department of Pediatrics, Bambino Gesù Pediatric Hospital, Vatican City, Rome, Italy.
²² King's College London Allergy Academy, London, UK.
²³ Section of Allergology, Department of Internal Medicine, Erasmus Medical Center, Building Rochussenstraat, Rotterdam, The Netherlands.
²⁴ Unidad Alergia and Asma, Hospital San Bernardo, Salta, Argentina.
²⁵ Skin and Allergy Hospital, Helsinki University Hospital, Helsinki, Finland.
²⁶ Hans Christian Andersen Children's Hospital, Odense University Hospital, Odense, Denmark.
²⁷ Clinical Department of Otorhinolaryngology, Head and Neck Surgery, University Hospitals Leuven, KU Leuven, Louvain, Belgium.
²⁸ Allergy Learning and Consulting, Secretary Immunotherapy Interest Group EAACI, Copenhagen, Denmark.
²⁹ Allergology Department, Centre de l'Asthme et des Allergies, Hôpital d'Enfants Armand-Trousseau, INSERM, UMR_S 1136, Sorbonne Universités, UPMC Univ Paris, Institut Pierre Louis d'Epidémiologie et de Santé Publique, Equipe EPAR, Paris, France.
³⁰ Hospital Sírio Libanês, São Paulo, Brazil ; University Hospital of Montpellier, Montpellier, France ; UPMC Paris 06, UMR-S 1136, IPLESP, Equipe EPAR, Sorbonne Universités, Paris, France.
³¹ Allergy and Asthma Center Westend, Outpatient Clinic and Clinical Research Center, Ackermann, Hanf, & Kleine-Tebbe, Berlin, Germany.
³² Center for Rhinology and Allergology, German Society for Otorhinolaryngology HNS, Wiesbaden, Germany.
³³ Departments of Immunology and Dermatology/Allergology, University Medical Center Utrecht, Heidelberglaan, Utrecht, The Netherlands.
³⁴ Medical University of Lodz, Lodz, Poland.
³⁵ ARIA, Mexico, DF Mexico ; AAAAI, Hospital Médica Sur, Mexico, DF Mexico.
³⁶ Research Centre for Prevention and Health, The Capital Region of Denmark, Copenhagen, Denmark ; Department of Clinical Experimental Research, Rigshospitalet, Copenhagen, Denmark ; Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
³⁷ Pediatric Pneumology and Immunology, Charité Medical University, Berlin, Germany.
³⁸ Danish Allergy Centre, Allergy Clinic, Gentofte University Hospital, Hellerup, Denmark.
³⁹ IMSIE, Klinikum der Universität zu Köln A. ö. R., Cologne, Germany.
⁴⁰ Unitat de Rinologia i Clínica de l'Olfacte, ENT Department, Hospital Clínic, Clinical and Experimental Respiratory Immunoallergy, IDIBAPS, CIBERES, Barcelona, Catalonia Spain.
⁴¹ Department of Women and Child Health, Food Allergy Referral Centre Veneto Region, Padua General University Hospital, Padua, Italy.
⁴² Allergy Unit, 2nd Pediatric Clinic, University of Athens, Athens, Greece.
⁴³ Allergy and Respiratory Diseases, IRCCS San Martino-IST, Univesity of Genoa, Genoa, Italy.
⁴⁴ ASST Grande Ospedale Metropolitano Niguarda, P.zza Ospedale Maggiore, Milan, Italy.
⁴⁵ Department of Otorhinolaryngology, Head and Neck Surgery, Universitätsmedizin Mannheim, Mannheim, Germany ; Medical Faculty Mannheim, Heidelberg University, Heidelberg, Germany ; Center for Rhinology and Allergology, Wiesbaden, Germany.
⁴⁶ Division of Applied Health Sciences, Primary Care Respiratory Medicine, Academic Primary Care, University of Aberdeen, Aberdeen, Scotland, UK ; Research in Real Life (RiRL), Oakington, Cambridge, UK ; Optimum Patient Care Ltd, Singapore, Singapore.
⁴⁷ Allergy Section, Hospital Infantil Universitario Niño Jesús, Madrid, Spain.
⁴⁸ Department of Dermatology and Allergology, Ludwig-Maximillian University, Munich, Germany.
⁴⁹ Department of Prevention of Environmental Hazards and Allergology, Medical University of Warsaw, Warsaw, Poland.
⁵⁰ Royal National Throat, Nose and Ear Hospital, London, UK ; University College London, London, UK.
⁵¹ Clinical Trials Center, University Hospital of Zurich, Zurich, Switzerland.
⁵² Immunomodulation and Tolerance Group, Allergy and Clinical Immunology, Inflammation, Repair and Development Section, National Heart and Lung Institute, Faculty of Medicine, Imperial College London, London, UK ; MRC and Asthma UK Centre in Allergic Mechanisms of Asthma, London, UK.
⁵³ Asthma UK Centre for Applied Research, Centre for Medical Informatics, Usher Institute of Population Health Sciences and Informatics, The University of Edinburgh, Teviot Place, Edinburgh, EH8 9AG UK.
⁵⁴ SLAAI, Asuncion, Paraguay.
⁵⁵ Programa de Pòs-Graduação em Pediatria e Ciências Aplicadas à Pediatria, Departamento de Pediatria EPM, UNIFESP, São Paulo, Brazil.
⁵⁶ Department of Dermatology and Venerology, Medical University of Graz, Graz, Austria ; Allergy Outpatient Clinic Reumannplatz, Vienna, Austria.
⁵⁷ Servicio de Alergologia, Complejo Hospitalario de Navarra, Pamplona, Spain.
⁵⁸ Departments of Experimental Immunology and Otorhinolaryngology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands.
⁵⁹ Unit of Geriatric Immunoallergology, Interdisciplinary Department of Medicine, University of Bari Medical School, Bari, Italy.
⁶⁰ Allergy Department, Complejo Hospitalario Universitario de Santiago de Compostela, Santiago de Compostela, Spain.
⁶¹ Respiratory and Allergic Disease Division, Department of Paediatrics, Medical University of Graz, Graz, Austria.
⁶² Allergie-Centrum-Charité, Klinik für Dermatologie, Venerologie und Allergologie, Charité-Universitätsmedizin Berlin, Berlin, Germany.
⁶³ University Hospital of Montpellier, Montpellier, France ; Contre les MAladies Chroniques pour un VIeillissement Actif en Languedoc-Roussillon, European Innovation Partnership on Active and Healthy Ageing Reference Site, Paris, France ; INSERM, VIMA, U1168, Ageing and Chronic Diseases, Epidemiological and Public Health Approaches, Paris, France ; UVSQ, UMR-S 1168, Université Versailles St-Quentin-en-Yvelines, Versailles Cedex, France ; CHRU, 371 Avenue du Doyen Gaston Giraud, 34295 Montpellier Cedex 5, France.

PMID: 27895895
PMCID: PMC5120439
DOI: 10.1186/s13601-016-0131-x

Abstract

Allergic diseases often occur early in life and persist throughout life. This life-course perspective should be considered in allergen immunotherapy. In particular it is essential to understand whether this al treatment may be used in old age adults. The current paper was developed by a working group of AIRWAYS integrated care pathways for airways diseases, the model of chronic respiratory diseases of the European Innovation Partnership on active and healthy ageing (DG CONNECT and DG Santé). It considered (1) the political background, (2) the rationale for allergen immunotherapy across the life cycle, (3) the unmet needs for the treatment, in particular in preschool children and old age adults, (4) the strategic framework and the practical approach to synergize current initiatives in allergen immunotherapy, its mechanisms and the concept of active and healthy ageing.

Keywords: AIRWAYS ICPs; Ageing; Allergen immunotherapy; Asthma; EIP on AHA; Rhinitis.

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References

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