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. 2016 Dec 20;17(1):76-81.
doi: 10.1039/c6lc01217e.

On-chip integration of organic synthesis and HPLC/MS analysis for monitoring stereoselective transformations at the micro-scale

Josef J Heiland  1 , Rico Warias  1 , Carsten Lotter  1 , Laura Mauritz  1 , Patrick J W Fuchs  2 , Stefan Ohla  1 , Kirsten Zeitler  2 , Detlev Belder  1
Affiliations

On-chip integration of organic synthesis and HPLC/MS analysis for monitoring stereoselective transformations at the micro-scale

Josef J Heiland et al. Lab Chip. .

Abstract

We present a microfluidic system, seamlessly integrating microflow and microbatch synthesis with a HPLC/nano-ESI-MS functionality on a single glass chip. The microfluidic approach allows to efficiently steer and dispense sample streams down to the nanoliter-range for studying reactions in quasi real-time. In a proof-of-concept study, the system was applied to explore amino-catalyzed reactions, including asymmetric iminium-catalyzed Friedel-Crafts alkylations in microflow and micro confined reaction vessels.

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