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Review
. 2016 Dec;35(4):515-524.
doi: 10.1007/s10555-016-9637-x.

PI3K/AKT/mTOR: role in breast cancer progression, drug resistance, and treatment

Angel Guerrero-Zotano  1 , Ingrid A Mayer  1 , Carlos L Arteaga  2
Affiliations
Review

PI3K/AKT/mTOR: role in breast cancer progression, drug resistance, and treatment

Angel Guerrero-Zotano et al. Cancer Metastasis Rev. 2016 Dec.

Abstract

Anti-cancer cancer-targeted therapies are designed to exploit a particular vulnerability in the tumor, which in most cases results from its dependence on an oncogene and/or loss of a tumor suppressor. Mutations in the phosphoinositide 3-kinase (PI3K)/AKT/mTOR pathway are freqcuently found in breast cancers and associated with cellular transformation, tumorigenesis, cancer progression, and drug resistance. Several drugs targeting PI3K/ATK/mTOR are currently in clinical trials, mainly in combination with endocrine therapy and anti-HER2 therapy. These drugs are the focus of this review.

Keywords: AKT; Breast cancer; PI3K; mTOR.

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