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. 2016 Dec;18(12):1221-1228.
doi: 10.1007/s12094-016-1579-9. Epub 2016 Nov 28.

SEOM Clinical Guideline for gastrointestinal sarcomas (GIST) (2016)

Affiliations

SEOM Clinical Guideline for gastrointestinal sarcomas (GIST) (2016)

A Poveda et al. Clin Transl Oncol. 2016 Dec.

Abstract

Gastrointestinal stromal tumors (GISTs) are the most common mesenchymal neoplasms of the digestive tract, and this disease has served as a paradigmatic model for successful rational development of targeted therapies. The introduction of tyrosine kinase inhibitors with activity against KIT/PDGFRA in both localized and advanced stages has remarkably improved the survival in a disease formerly deemed resistant to all systemic therapies. The Spanish Society of Medical Oncology (SEOM) guidelines provide a multidisciplinary and updated consensus for the diagnosis and treatment of GIST patients. We strongly encourage that the managing of these patients should be performed within multidisciplinary teams in reference centers.

Keywords: GIST; Imatinib; Regorafenib; Sunitinib.

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Conflict of interest statement

None.

Figures

Fig. 1
Fig. 1
Algorithm of imaging techniques in GIST

References

    1. Poveda A, Rivera F, Martin J. SEOM guidelines for gastrointestinal stromal sarcomas (GIST) Clin Transl Oncol Off Publ Fed Span Oncol Soc Natl Cancer Inst Mexico. 2012;14(7):536–540. - PubMed
    1. Kalkmann J, Zeile M, Antoch G, Berger F, Diederich S, Dinter D, et al. Consensus report on the radiological management of patients with gastrointestinal stromal tumours (GIST): recommendations of the German GIST Imaging Working Group. Cancer Imaging Off Publ Int Cancer Imaging Soc. 2012;12:126–135. - PMC - PubMed
    1. Bensimhon D, Soyer P, Boudiaf M, Fargeaudou Y, Nemeth J, Pocard M, et al. Imaging of gastrointestinal stromal tumors. J Radiol. 2009;90(4):469–480. doi: 10.1016/S0221-0363(09)74006-5. - DOI - PubMed
    1. Choi H, Charnsangavej C, Faria SC, Macapinlac HA, Burgess MA, Patel SR, et al. Correlation of computed tomography and positron emission tomography in patients with metastatic gastrointestinal stromal tumor treated at a single institution with imatinib mesylate: proposal of new computed tomography response criteria. J Clin Oncol Off J Am Soc Clin Oncol. 2007;25(13):1753–1759. doi: 10.1200/JCO.2006.07.3049. - DOI - PubMed
    1. Miettinen M, Lasota J, Sobin LH. Gastrointestinal stromal tumors of the stomach in children and young adults: a clinicopathologic, immunohistochemical, and molecular genetic study of 44 cases with long-term follow-up and review of the literature. Am J Surg Pathol. 2005;29(10):1373–1381. doi: 10.1097/01.pas.0000172190.79552.8b. - DOI - PubMed

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