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. 2016 Nov 29;13(11):e1002182.
doi: 10.1371/journal.pmed.1002182. eCollection 2016 Nov.

The Dengue Vaccine Dilemma: Balancing the Individual and Population Risks and Benefits

Jacqueline Deen  1
Affiliations

The Dengue Vaccine Dilemma: Balancing the Individual and Population Risks and Benefits

Jacqueline Deen. PLoS Med. .

Abstract

In a Perspective, Jacqueline Deeen discusses challenges in balancing the individual and population risks and benefits for CYD-TDV (Dengvaxia), the first available dengue vaccine.

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Conflict of interest statement

I have read the journal's policy and have the following conflicts: I was an unpaid external consultant in the "Extended Study Group for dengue vaccine effectiveness evaluation studies in Asia” from 6 April 2015 to 31 August 2015 convened by Sanofi Pasteur. I was a WHO temporary adviser in a meeting entitled “Targeting Vaccination and Post-licensure Studies for the Licensed Dengue Vaccine” in Geneva from 14 to 15 June 2016 convened by the WHO. I am an unpaid co-investigator of a study entitled “Effectiveness of the tetravalent dengue vaccine, CYD-TDV (Dengvaxia) in the Philippines” currently in preparation, sponsored by the University of the Philippines-Manila and funded by Sanofi Pasteur.

References

    1. Simmons CP, Farrar JJ, Nguyen VV, Wills B (2012) Dengue. N Engl J Med 366: 1423–1432. 10.1056/NEJMra1110265 - DOI - PubMed
    1. WHO/TDR (2009) Dengue: Guidelines for Diagnosis, Treatment, Prevention and Control: New Edition. Geneva. - PubMed
    1. Olkowski S, Forshey BM, Morrison AC, Rocha C, Vilcarromero S, et al. (2013) Reduced risk of disease during postsecondary dengue virus infections. J Infect Dis 208: 1026–1033. 10.1093/infdis/jit273 - DOI - PMC - PubMed
    1. Thomas SJ, Rothman AL (2015) Trials and Tribulations on the Path to Developing a Dengue Vaccine. Am J Prev Med 49: S334–344. 10.1016/j.amepre.2015.09.006 - DOI - PubMed
    1. Halstead SB (2016) Licensed Dengue Vaccine: Public Health Conundrum and Scientific Challenge. Am J Trop Med Hyg 95: 741–745. 10.4269/ajtmh.16-0222 - DOI - PMC - PubMed

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