Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2016 Oct;43(5):548-553.
doi: 10.1053/j.seminoncol.2016.09.002. Epub 2016 Sep 22.

Familial pancreatic cancer

Gloria M Petersen  1
Affiliations
Review

Familial pancreatic cancer

Gloria M Petersen. Semin Oncol. 2016 Oct.

Abstract

Familial pancreatic cancer (FPC) includes those kindreds that contain at least two first-degree relatives with pancreatic ductal adenocarcinoma. At least 12 known hereditary syndromes or genes are associated with increased risk of developing pancreatic cancer, the foremost being BRCA2 and CDKN2A. Research into the identification of mutations in known cancer predisposition genes and through next-generation sequencing has revealed extensive heterogeneity. The development of genetic panel testing has enabled genetic risk assessment and predisposition testing to be routinely offered. Precision oncology has opened the possibility of "incidental" germline mutations that may have implications for family members. However, in both cases, evidence-based recommendations for managing patients and at-risk family members in light of genetic status remain emergent, with current practice based on expert opinion.

Keywords: BRCA2; CDKN2A; Genetic testing; Pancreatic cancer.

PubMed Disclaimer

Conflict of interest statement

The author has no conflicts of interest or disclosures

References

    1. Siegel RL, Miller KD, Jemal A. Cancer statistics, 2016. CA Cancer J Clin. 2016 Jan;66(1):7–30. - PubMed
    1. Yancik R, Ries LA. Cancer in older persons. Magnitude of the problem–how do we apply what we know? Cancer. 1994 Oct 1;74(7 Suppl):1995–2003. - PubMed
    1. Rahib L, Smith BD, Aizenberg R, Rosenzweig AB, Fleshman JM, Matrisian LM. Projecting cancer incidence and deaths to 2030: the unexpected burden of thyroid, liver, and pancreas cancers in the United States. Cancer Res. 2014 Jun 1;74(11):2913–2921. - PubMed
    1. Hruban RH, Petersen GM, Goggins M, et al. Familial pancreatic cancer. Annals of oncology : official journal of the European Society for Medical Oncology / ESMO. 1999;10(Suppl 4):69–73. - PubMed
    1. McWilliams RR, Rabe KG, Olswold C, De Andrade M, Petersen GM. Risk of malignancy in first-degree relatives of patients with pancreatic carcinoma. Cancer. 2005 Jul 15;104(2):388–394. - PubMed

MeSH terms

Substances