Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2017 Jan 4;45(D1):D543-D550.
doi: 10.1093/nar/gkw1003. Epub 2016 Nov 28.

The EcoCyc database: reflecting new knowledge about Escherichia coli K-12

Affiliations

The EcoCyc database: reflecting new knowledge about Escherichia coli K-12

Ingrid M Keseler et al. Nucleic Acids Res. .

Abstract

EcoCyc (EcoCyc.org) is a freely accessible, comprehensive database that collects and summarizes experimental data for Escherichia coli K-12, the best-studied bacterial model organism. New experimental discoveries about gene products, their function and regulation, new metabolic pathways, enzymes and cofactors are regularly added to EcoCyc. New SmartTable tools allow users to browse collections of related EcoCyc content. SmartTables can also serve as repositories for user- or curator-generated lists. EcoCyc now supports running and modifying E. coli metabolic models directly on the EcoCyc website.

PubMed Disclaimer

Figures

Figure 1.
Figure 1.
Transporter classes in EcoCyc.
Figure 2.
Figure 2.
Sulfoquinovose degradation pathway.
Figure 3.
Figure 3.
Zoom levels of the genome browser, with the previously available ‘genes’ and ‘sites’ levels compared to the new ‘sequence’ level.
Figure 4.
Figure 4.
Running metabolic models on the EcoCyc web site.

References

    1. McClung D.J., Calixto A., Mosera M.N., Kumar R., Neidle E.L., Elliott K.T. Novel heterologous bacterial system reveals enhanced susceptibility to DNA damage mediated by yqgF, a nearly ubiquitous and often essential gene. Microbiology. 2016;162:1808–1821. - PubMed
    1. Keseler I.M., Mackie A., Peralta-Gil M., Santos-Zavaleta A., Gama-Castro S., Bonavides-Martinez C., Fulcher C., Huerta A.M., Kothari A., Krummenacker M., et al. EcoCyc: fusing model organism databases with systems biology. Nucleic Acids Res. 2013;41:D605–D612. - PMC - PubMed
    1. Karp P.D., Weaver D., Paley S., Fulcher C., Kubo A., Kothari A., Krummenacker M., Subhraveti P., Weerasinghe D., Gama-Castro S., et al. The EcoCyc database. EcoSal Plus. 2014;2014 - PMC - PubMed
    1. Weaver D.S., Keseler I.M., Mackie A., Paulsen I.T., Karp P.D. A genome-scale metabolic flux model of Escherichia coli K-12 derived from the EcoCyc database. BMC Syst. Biol. 2014;8:79. - PMC - PubMed
    1. Karp P.D., Latendresse M., Paley S.M., Krummenacker M., Ong Q.D., Billington R., Kothari A., Weaver D., Lee T., Subhraveti P., et al. Pathway Tools version 19.0 update: software for pathway/genome informatics and systems biology. Brief Bioinform. 2015;17:877–890. - PMC - PubMed

Publication types

MeSH terms

Substances