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. 2017 Jan 4;45(D1):D177-D182.
doi: 10.1093/nar/gkw1062. Epub 2016 Nov 29.

The neXtProt knowledgebase on human proteins: 2017 update

Pascale Gaudet  1   2 , Pierre-André Michel  3 , Monique Zahn-Zabal  3 , Aurore Britan  3 , Isabelle Cusin  3 , Marcin Domagalski  3   2 , Paula D Duek  3 , Alain Gateau  3 , Anne Gleizes  3 , Valérie Hinard  3 , Valentine Rech de Laval  3   2 , JinJin Lin  4 , Frederic Nikitin  3 , Mathieu Schaeffer  3   2 , Daniel Teixeira  3 , Lydie Lane  3   2 , Amos Bairoch  3   2
Affiliations

The neXtProt knowledgebase on human proteins: 2017 update

Pascale Gaudet et al. Nucleic Acids Res. .

Abstract

The neXtProt human protein knowledgebase (https://www.nextprot.org) continues to add new content and tools, with a focus on proteomics and genetic variation data. neXtProt now has proteomics data for over 85% of the human proteins, as well as new tools tailored to the proteomics community.Moreover, the neXtProt release 2016-08-25 includes over 8000 phenotypic observations for over 4000 variations in a number of genes involved in hereditary cancers and channelopathies. These changes are presented in the current neXtProt update. All of the neXtProt data are available via our user interface and FTP site. We also provide an API access and a SPARQL endpoint for more technical applications.

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Figures

Figure 1.
Figure 1.
New Phenotype View for the MSH6 entry. (A) Phenotypes section. (B) Variants sections.
Figure 2.
Figure 2.
Excerpt of the Ion channel variants portal.
Figure 3.
Figure 3.
Peptide unicity checker user interface. A list of peptides provided by the user (separated by a space, a comma, a semi-colon or a carriage return) is verified for their unicity in neXtProt sequences by hitting the ‘Check’ button. Users have the option to take into account variants for determining unicity.
See this image and copyright information in PMC

References

    1. Gaudet P., Michel P.A., Zahn-Zabal M., Cusin I., Duek P.D., Evalet O., Gateau A., Gleizes A., Pereira M., Teixeira D., et al. The neXtProt knowledgebase on human proteins: current status. Nucleic Acids Res. 2015;43:D764–D770. - PMC - PubMed
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