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. 2016 Nov;12(5):3041-3044.
doi: 10.3892/ol.2016.5093. Epub 2016 Sep 5.

Genetics and epigenetics of melanoma

Xiao-Ying Zhang  1 , Pei-Ying Zhang  2
Affiliations

Genetics and epigenetics of melanoma

Xiao-Ying Zhang et al. Oncol Lett. 2016 Nov.

Retraction in

  • Genetics and epigenetics of melanoma.
    Zhang XY, Zhang PY. Zhang XY, et al. Oncol Lett. 2020 Nov;20(5):184. doi: 10.3892/ol.2020.12045. Epub 2020 Sep 1. Oncol Lett. 2020. PMID: 32934751 Free PMC article.

Abstract

Cancer affects multiple organs in the body Malignant melanoma involves the invasion of skin and occasionally mucosal membrane or eye choroidal tissues. The incidence of cutaneous malignant melanoma is on the increase worldwide and is a major concern in current research. The increase is associated with UV irradiation-induced genetic aberrations that stimulate skin melanocytes to develop unlimited growth. This eventually leads to cell immortality, which in turn causes metastases. The present review examines the genetics and epigenetics of this pathological state together with recent perspectives of the therapeutic management of disease.

Keywords: epigenetics; genetics; melanoma.

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