Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Meta-Analysis
. 2016 Nov 30:6:38024.
doi: 10.1038/srep38024.

Analgesic effect and safety of single-dose intra-articular magnesium after arthroscopic surgery: a systematic review and meta-analysis

Chao Zeng  1 , Yu-Sheng Li  1 , Jie Wei  2   3 , Dong-Xing Xie  1 , Xi Xie  1 , Liang-Jun Li  1 , Shu-Guang Gao  1 , Wei Luo  1 , Yi-Lin Xiong  1 , Wen-Feng Xiao  1 , Guang-Hua Lei  1
Affiliations
Meta-Analysis

Analgesic effect and safety of single-dose intra-articular magnesium after arthroscopic surgery: a systematic review and meta-analysis

Chao Zeng et al. Sci Rep. .

Abstract

To examine the analgesic effect and safety of single-dose intra-articular (IA) magnesium (Mg) after arthroscopic surgery. Pubmed, Embase and Cochrane library were searched through in January 2016. Eight RCTs and eight experimental studies were included. The IA Mg exhibited a significantly lower pain score when compared with placebo (MD, -0.41, 95% CI, -0.78 to -0.05, p = 0.03). There was no significant difference between Mg and bupivacaine in terms of pain relief and the time to first analgesic request. Furthermore, statistically significant differences both in pain score (MD, -0.62, 95% CI, -0.81 to -0.42, p < 0.00001) and time to first analgesic request (MD, 6.25, 95% CI, 5.22 to 7.29, p < 0.00001) were observed between Mg plus bupivacaine and bupivacaine alone. There was no statistically significant difference among the various groups with respect to adverse reactions. Most of the included in vitro studies reported the chondrocyte protective effect of Mg supplementation. There were also two in vivo studies showing the cartilage protective effect of IA Mg. The single-dose IA Mg following arthroscopic surgery was effective in pain relief without increasing adverse reactions, and it could also enhance the analgesic effect of bupivacaine. In addition, Mg seemed to possess the cartilage or chondrocyte protective effect based on experimental studies.

PubMed Disclaimer

Figures

Figure 1
Figure 1. Flow diagram of included studies.
Figure 2
Figure 2. Forest plot of pain intensity at the last follow-up time point.
Figure 3
Figure 3. Forest plot of time to first analgesic request.
See this image and copyright information in PMC

References

    1. Gelici Oral E., Hanci A., Ulufer Sivrikaya G., Dobrucali H. & Turkoglu Kilinc L. The analgesic effects of morphine and tramadol added to intra-articular Levobupivacaine-Tenoxicam combination for arthroscopic knee surgery on postoperative pain; A randomized clinical trial. Anesth Pain Med. 5 (2015). - PMC - PubMed
    1. Moura E. C. et al. Minimum effective concentration of bupivacaine in Ultrasound-Guided femoral nerve block after arthroscopic knee meniscectomy: A randomized, Double-Blind, controlled trial. Pain Physician. 19, E79–E86 (2016). - PubMed
    1. Zeng C. et al. Single-Dose Intra-Articular morphine after arthroscopic knee surgery: A Meta-Analysis of randomized Placebo-Controlled studies. Arthroscopy. 29, 1450–1458 (2013). - PubMed
    1. Wei J. et al. Single-dose intra-articular bupivacaine versus morphine after arthroscopic knee surgery. Clin J Pain. 1 (2014). - PubMed
    1. Wei J., Yang H. B., Qin J. B., Kong F. J. & Yang T. B. Single-dose intra-articular bupivacaine after knee arthroscopic surgery: A meta-analysis of randomized placebo-controlled studies. Knee Surg Sports Traumatol Arthrosc. 22, 1517–1528 (2014). - PubMed

Publication types

LinkOut - more resources