Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Observational Study
. 2016 Nov-Dec;60(6):532-536.
doi: 10.1590/2359-3997000000221. Epub 2016 Nov 24.

Hypoparathyroidism and pseudohypoparathyroidism: etiology, laboratory features and complications

Maicon Piana Lopes  1 , Breno S Kliemann  1 , Ileana Borsato Bini  1 , Rodrigo Kulchetscki  1 , Victor Borsani  1 , Larissa Savi  1 , Victoria Z C Borba  1   2 , Carolina A Moreira  1   2   3
Affiliations
Observational Study

Hypoparathyroidism and pseudohypoparathyroidism: etiology, laboratory features and complications

Maicon Piana Lopes et al. Arch Endocrinol Metab. 2016 Nov-Dec.

Abstract

Objectives: To identify a clinical profile and laboratory findings of a cohort of hypoparathyroidism patients and determine the prevalence and predictors for renal abnormalities.

Materials and methods: Data from medical records of five different visits were obtained, focusing on therapeutic doses of calcium and vitamin D, on laboratory tests and renal ultrasonography (USG).

Results: Fifty-five patients were identified, 42 females and 13 males; mean age of 44.5 and average time of the disease of 11.2 years. The most frequent etiology was post-surgical. Levels of serum calcium and creatinine increased between the first and last visits (p < 0.001 and p < 0.05, respectively); and serum levels of phosphate decreased during the same period (p < 0.001). Out of the 55 patients, 40 had USG, and 10 (25%) presented with kidney calcifications. There was no significant difference in the amount of calcium and vitamin D doses among patients with kidney calcifications and others. No correlation between serum and urinary levels of calcium and the presence of calcification was found. Urinary calcium excretion in 24h was significantly higher in patients with kidney calcification (3.3 mg/kg/d) than in those without calcification (1.8 mg/kg/d) (p < 0.05).

Conclusions: The reduction of hypocalcemia and hyperphosphatemia suggest an effectiveness of the treatment, and the increase in serum creatinine demonstrates an impairment of renal function during follow-up. Kidney calcifications were prevalent in this cohort, and higher urinary calcium excretion, even if still within the normal range, was associated with development of calcification. These findings suggest that lower rates of urinary calcium excretion should be aimed for in the management of hypoparathyroidism.

PubMed Disclaimer

Conflict of interest statement

Disclosure: no potential conflict of interest relevant to this article was reported.

Figures

Figure 1
Figure 1. Follow-up of laboratorial findings according to the presence of renal calcification.
Figure 2
Figure 2. Distribution of patients according their renal failure stage.
See this image and copyright information in PMC

References

    1. .Sociedade Brasileira de Endocrinologia. Hipoparatireoidismo: diagnóstico e tratamento; 2012. p. 1-30.
    1. .Maeda SS, Fortes EM, Oliveira UM, Borba VC, Lazaretti-Castro M. Hypoparathyroidism and pseudohypoparathyroidism. Arq Bras Endocrinol Metabol. 2006;50(4):664-73. - PubMed
    1. .Peacock M. Calcium metabolism in health and disease. Clin J Am Soc Nephrol. 2010;5 Suppl 1:S23-30. - PubMed
    1. .Menon MC, Ix JH. Dietary phosphorus, serum phosphorus, and cardiovascular disease. Ann N Y Acad Sci. 2013;1301:21-6. - PubMed
    1. .Bilezikian JP, Khan A, Potts JT Jr, Brandi ML, Clarke BL, Shoback D, et al. Hypoparathyroidism in the adult: epidemiology, diagnosis, pathophysiology, target-organ involvement, treatment, and challenges for future research. J Bone Miner Res. 2011;26(10):2317-37. - PMC - PubMed

Publication types

MeSH terms

LinkOut - more resources