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Multicenter Study
. 2016 Nov;74(11):914-920.
doi: 10.1590/0004-282X20160129.

Brazilian-Portuguese translation, cross-cultural adaptation and validation of the Myasthenia Gravis Composite scale. A multicentric study

Ezequiel Fernandes Oliveira  1 , Valéria Cavalcante Lima  2 , Eduardo Araujo Perez  3 , Melissa Nunes Polaro  4 , Berenice Cataldo Oliveira Valério  4 , João R Pereiro  5 , Sergio Roberto Nacif  5 , Claudia Santos Oliveira  1 , Acary Souza Bulle Oliveira  2 , Luis Vicente Franco Oliveira  1
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Free article
Multicenter Study

Brazilian-Portuguese translation, cross-cultural adaptation and validation of the Myasthenia Gravis Composite scale. A multicentric study

Ezequiel Fernandes Oliveira et al. Arq Neuropsiquiatr. 2016 Nov.
Free article

Abstract

Objective: To perform the translation, cultural adaptation and validation of the Myasthenia Gravis Composite (MGC) scale in Brazil.

Methods: The study was conducted at three neuromuscular disease research centers in accordance with the international ethical standards, following a multi-modal approach and was conducted in three steps consisting of translation, cultural adaptation, and validation according to international guidelines. The final version of the MGC was applied in a sample of 27 MG patients and the total score was compared to a Portuguese version of the MG-QOL-15.

Results: The internal consistency verified by Cohen's Kappa test was excellent (0.766). The correlation between the MGC and MG-QOL-15 was strong (R = 0.777; p = 0.000). No significant differences were found between the responses of patients in the first and second applications of the MGC.

Conclusion: The MGC scale, validated into Brazilian Portuguese, has proven to be a reliable instrument that is easy to use, and is highly reproducible.

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