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. 2017 Jan 2;35(1):36-42.
doi: 10.1080/07357907.2016.1247455. Epub 2016 Nov 30.

The High Frequency of PIK3CA Mutations in Iranian Breast Cancer Patients

Ghasem Azizi Tabesh  1 , Pantea Izadi  1 , Forouzandeh Fereidooni  2 , Amir Nader Emami Razavi  2 , Javad Tavakkoly Bazzaz  1
Affiliations

The High Frequency of PIK3CA Mutations in Iranian Breast Cancer Patients

Ghasem Azizi Tabesh et al. Cancer Invest. .

Abstract

In breast cancer, somatic mutations of PIK3CA oncogene are common. We investigated the mutational status of exons 9 and 20 of the PIK3CA gene by polymerase chain reaction and direct sequencing in 80 breast tumors, and observed that 45% of these contained PIK3CA mutations in the mentioned exons. These mutations were found more in progesterone receptor positive and Her2- tumors, but this association did not reach a statistically significant level. Also, we observed a significant association between PIK3CA mutations and low-grade tumors. In our study, PIK3CA mutations were related to good and moderate prognosis in breast cancer patients.

Keywords: Breast cancer; PIK3CA; somatic mutation.

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