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. 1978 Aug;75(8):4033-6.
doi: 10.1073/pnas.75.8.4033.

Temperature-sensitive mutants of mouse hepatitis virus produce a high incidence of demyelination

M V Haspel, P W Lampert, M B Oldstone

Temperature-sensitive mutants of mouse hepatitis virus produce a high incidence of demyelination

M V Haspel et al. Proc Natl Acad Sci U S A. 1978 Aug.

Abstract

Mutagenesis of mouse hepatitis virus with 5-azacytidine or 5-fluorouracil yielded several temperature-sensitive mutants. Mutants have been isolated that dramatically enhance the production of demyelinating disease over that previously noted with the wild-type virus. This reproducible model should now make possible the precise elucidation of the pathogenic mechanism and molecular basis of this virus-induced demyelination.

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