Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2016 Dec 1;16(1):725.
doi: 10.1186/s12879-016-2061-6.

Central-line associated bloodstream infections in a tertiary care children's University hospital: a prospective study

Elisabetta Venturini  1 , Carlotta Montagnani  1 , Alessandra Benni  1 , Sabrina Becciani  1 , Klaus Peter Biermann  2 , Salvatore De Masi  2 , Elena Chiappini  1 , Maurizio de Martino  1 , Luisa Galli  3   4   5 ; CLABSI (central-line associated bloodstream infections) study group
Collaborators, Affiliations

Central-line associated bloodstream infections in a tertiary care children's University hospital: a prospective study

Elisabetta Venturini et al. BMC Infect Dis. .

Abstract

Background: The central-line associated bloodstream infections (CLABSI) are the most common healthcare-associated infections in childhood. Despite the international data available on healthcare-associated infections in selected groups of patients, there is a lack of large and good quality studies. The present survey is the first prospective study monitoring for 6 months the occurrence of central-line associated bloodstream infections in all departments of an Italian tertiary care children's university hospital.

Methods: The study involved all children aged less than 18 years admitted to Meyer Children's University Hospital, Florence, Italy who had a central line access between the October 15th, 2014 and the April 14th, 2015. CLABSI were defined according to the Center for Disease Control and Prevention criteria. CLABSI incidence rates with 95% confidence limits were calculated and stratified for the study variables. For each factor the relative risk and 95% confidence intervals were evaluated. Statistical analysis was performed using the statistical software SPSS for Windows, version 22.0 (SPSS Inc., Chicago, IL), p < 0.05 was considered statistically significant.

Results: CLABSI rate was 3.73/1000 (95% CI: 2.54-5.28) central line-days. A higher CLABSI incidence was seen with female gender (p = 0.045) and underlying medical conditions (excepting prematurity, surgical diseases and malignancy) (p = 0.06). In our study 5 infections, were caused by extended-spectrum β-lactamase producing organisms and in one case by carbapenem-resistant Klebsiella pneumoniae.

Conclusions: Our study confirms the spreading of multi-resistant pathogens as causes of healthcare associated infections in children. An increased incidence rate of CLABSI in our study was related to underlying medical conditions. Pediatric studies focusing on healthcare infections in this type of patients should be done in order to deepen our understanding on associated risk factors and possible intervention areas.

Keywords: CLABSI; Central-line; Children; Infection.

PubMed Disclaimer

Figures

Fig. 1
Fig. 1
Microorganisms identified in children with CLABSI. The complete list of the microorganisms found is displayed in the figure. The pathogens isolated in patients with CLABSI are mainly Enterobacteriaceae and Candida spp. Five infections, out of the 9 cases caused by Enterobactriaceae identified are due to extended-spectrum β-lactamase producing organisms (3 Escherichia coli, 2 Klebsiella pneumoniae) and in one case by carbapenem-resistant Klebsiella pneumoniae. Specifically, Candida albicans has been identified in 5 (71.4%) patients and Candida parapsilosis in other 2 (28.6%) children
See this image and copyright information in PMC

References

    1. Rosenthal VD, Maki DG, Mehta Y, Leblebicioglu H, Memish ZA, Al-Mousa HH, et al. International Nosocomial Infection Control Consortium (INICC) report, data summary of 43 countries for 2007–2012, Device-associated module. Am J Infect Control. 2014;42:942–56. doi: 10.1016/j.ajic.2014.05.029. - DOI - PubMed
    1. European Centre for Disease Control and Prevention. Annual epidemiological report 2014-Antimicrobial resistance and healthcare-associated infections. 2014. http://ecdc.europa.eu/en/publications/surveillance_reports/annual_epidem.... Accessed 27 Jun 2016.
    1. Patrick SW, Kawai AT, Kleinman K, Jin R, Vaz L, Gay C, et al. Health care-associated infections among critically ill children in the US, 2007–2012. Pediatrics. 2014;134:705–12. doi: 10.1542/peds.2014-0613. - DOI - PubMed
    1. Bion J, Richardson A, Hibbert P, Beer J, Abrusci T, McCutcheon M, et al. ‘Matching Michigan’: a 2-year stepped interventional programme to minimise central venous catheter-blood stream infections in intensive care units in England. BMJ Qual Saf. 2013;22:110–23. doi: 10.1136/bmjqs-2012-001325. - DOI - PMC - PubMed
    1. Rutledge-Taylor K, Matlow A, Gravel D, Embree J, Le Saux N, Johnston L, et al. A point prevalence survey of health care-associated infections in Canadian pediatric inpatients. Am J Infect Control. 2012;40:491–6. doi: 10.1016/j.ajic.2011.08.008. - DOI - PubMed

LinkOut - more resources