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. 2017 Dec;16(4):464-472.
doi: 10.1177/1534735416679515. Epub 2016 Nov 30.

Influence of a Moderate-Intensity Exercise Program on Early NK Cell Immune Recovery in Pediatric Patients After Reduced-Intensity Hematopoietic Stem Cell Transplantation

Carolina Chamorro-Viña  1 , Jaime Valentín  2 , Lucía Fernández  3 , Marta González-Vicent  4 , Margarita Pérez-Ruiz  5 , Alejandro Lucía  5 , S Nicole Culos-Reed  1   6   7   8 , Miguel Ángel Díaz  4 , Antonio Pérez-Martínez  7
Affiliations

Influence of a Moderate-Intensity Exercise Program on Early NK Cell Immune Recovery in Pediatric Patients After Reduced-Intensity Hematopoietic Stem Cell Transplantation

Carolina Chamorro-Viña et al. Integr Cancer Ther. 2017 Dec.

Abstract

Introduction: After allogeneic hematopoietic stem cell transplantation (HSCT), NK cell reconstitution, which is crucial for positive outcomes, is dominated by the CD56bright subset with low NK cell cytotoxicity (NKCC) activity. Moderate exercise has been described as a potent NK cell stimulus in adults with cancer.

Purpose: To determine the effects of a moderate-intensity exercise program on NK cell recovery early after HSCT and the feasibility of this intervention.

Methods: Six children undergoing allogeneic HSCT were randomized to an exercise program (EP) or control (CT) group. The EP group performed a 10-week training combining in-hospital and home-based EP.

Results: We observed a significant increase in the posttraining/pretraining ratio of the CD56dim subset (EP = 1.27 ± 0.07; CT = 0.99 ± 0.08; P < .005) of the EP group. The ratio of NKCC was 8 times greater in the EP group.

Conclusion: Data suggest that a moderate-intensity EP program performed early after HSCT is feasible and might redistribute the CD56dim/CD56brigh NK cell subset, improving NKCC. The results are still preliminary and must be interpreted with caution.

Keywords: allogeneic stem cell transplantation; moderate-intensity exercise; natural killer cell cytotoxicity; natural killer cells.

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Conflict of interest statement

Declaration of Conflicting Interests: The author(s) declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article.

Figures

Figure 1.
Figure 1.
(A) Flow charts of NK cell subsets and (B) percentage of NK cell cytotoxicity (NKCC) against the K562 cell line at effector/target ratio 2.5:1 in the training (EP) and control (CT) groups before and after the EP.
Figure 2.
Figure 2.
(A) Performance in the functional test and (B) performance in the 6 repetition maximum test (6RM) in the training (EP) and control (CT) groups before and after the EP.
See this image and copyright information in PMC

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References

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