Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2016 Nov-Dec;61(6):678-680.
doi: 10.4103/0019-5154.193689.

A Case of Alkaptonuria with Degenerative Collagenous Plaques and Foot Drop

C Chandrakala  1 , Gurusami Karuvelan Tharini  1 , M Ananthi  1 , R Subha  1
Affiliations

A Case of Alkaptonuria with Degenerative Collagenous Plaques and Foot Drop

C Chandrakala et al. Indian J Dermatol. 2016 Nov-Dec.
No abstract available

PubMed Disclaimer

Conflict of interest statement

There are no conflicts of interest.

Figures

Figure 1
Figure 1
(a) Hyperkeratotic pigmented crateriform plaques in palms. (b) Hyperkeratotic pigmented plaques in heels. (c) Bluish green pigmentation of the ear. (d) Osler's sign in eye
Figure 2
Figure 2
(a) Black discoloration of urine after adding sodium hydroxide. (b) Benedict's test showing reducing substance in urine with negative control
Figure 3
Figure 3
(a) X-ray spine - narrowing of disc spaces and calcification of intervertebral discs. (b) Magnetic resonance imaging spine - disc degeneration and endplate degeneration
Figure 4
Figure 4
(a) X-ray leg calcification at Achilles tendon. (b) Magnetic resonance imaging leg ear at the central part of tendon Achilles and sparing of peripheral fibers
Figure 5
Figure 5
Dermis showing yellowish brown pigment deposition and collagen degeneration (H and E, ×100)
See this image and copyright information in PMC

References

    1. Fernández-Cañón JM, Granadino B, Beltrán-Valero de Bernabé D, Renedo M, Fernández-Ruiz E, Peñalva MA, et al. The molecular basis of alkaptonuria. Nat Genet. 1996;14:19–24. - PubMed
    1. La Du BN. Alkaptonuria. In: Scriver CR, Beaudet AL, Sly WS, editors. The Metabolic and Molecular Basis of Inherited Disease. 8th ed. McGraw-Hill: New York; 2001. pp. 219–23.
    1. Vasudevan B, Sawhney MP, Radhakrishnan S. Alkaptonuria associated with degenerative collagenous palmar plaques. Indian J Dermatol. 2009;54:299–301. - PMC - PubMed
    1. Seegmiller JE, Zannoni VG, Laster L, La Du BN. An enzymatic spectrophotometric method for the determination of homogentisic acid in plasma and urine. J Biol Chem. 1961;236:774–7. - PubMed
    1. Tharini G, Ravindran V, Hema N, Prabhavathy D, Parveen B. Alkaptonuria. Indian J Dermatol. 2011;56:194–6. - PMC - PubMed

LinkOut - more resources