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. 2016 Mar 15:21:15.
doi: 10.4103/1735-1995.178754. eCollection 2016.

Analysis of outcomes and prognostic factors of acute lymphoblastic leukemia patients treated by MCP841 protocol: A regional cancer center experience

Akhil Kapoor  1 , Ashok Kalwar  1 , Narender Kumar  2 , Mukesh Kumar Singhal  1 , Surender Beniwal  1 , Harvindra Singh Kumar  1
Affiliations

Analysis of outcomes and prognostic factors of acute lymphoblastic leukemia patients treated by MCP841 protocol: A regional cancer center experience

Akhil Kapoor et al. J Res Med Sci. .

Abstract

Background: A dramatic improvement in the survival of acute lymphoblastic leukemia (ALL) patients in the last three decades has been observed. MCP 841 protocol is an old but effective tool with tolerable toxicities. The objective of this study was to estimate the relapse-free survival of ALL patients treated uniformly with MCP 841 protocol on the basis of various prognostic factors.

Materials and methods: The study design was retrospective and it was conducted in a regional cancer center of Northwest India. Three hundred and ten ALL patients who underwent treatment with MCP 841 protocol and regular follow-up for up to 5 years were selected for this study. Relapse-free survival was calculated by Kaplan-Meier analysis and Cox regression analysis was used to calculate the hazards ratio (HR) using Statistical Package for the Social Sciences (SPSS) software for windows version 20.0.

Results: Fifty-four percent patients were <15 years of age and 69% were males. 53.2% patients were in remission at the end of 5 years of starting the treatment. Relapse-free survival at 5 years by Kaplan-Meir analysis for B-cell ALL was 62% [HR 0.67 {95% confidence interval (CI) 0.47-0.95}] with patients with unknown lineage taken as reference] while for T cell it was 28% [HR 1.41 (95% CI 1.19-1.63), P 0.001]. Patients with total leukocyte count (TLC) <1 lakh/cmm at presentation, relapse-free survival was 68% and those with TLC >1 lakh/cmm had 41% survival [HR 2.14 (1.76-2.48) with, P < 0.001].

Conclusion: MCP 841 protocol is a useful tool for the treatment of ALL in children when more aggressive protocols can not be used.

Keywords: Acute lymphoblastic leukemia (ALL); MCP 841 protocol; Northwest India; prognostic factors; survival analysis.

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Figures

Figure 1
Figure 1
Kaplan–Meier survival plot showing 5-year relapse-free survival probability for T-cell ALL and B-cell ALL
Figure 2
Figure 2
Survival plot showing 5-year relapse-free survival probability with total leukocyte count (TLC) at presentation against time
Figure 3
Figure 3
Kaplan–Meier plot showing agewise 5-year relapse-free survival probability plotted against time
See this image and copyright information in PMC

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