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. 2016 Dec;18(12):1213-1220.
doi: 10.1007/s12094-016-1574-1.

SEOM Clinical Guideline of management of soft-tissue sarcoma (2016)

A López-Pousa  1 , J Martin Broto  2 , J Martinez Trufero  3 , I Sevilla  4 , C Valverde  5 , R Alvarez  6 , J A Carrasco Alvarez  7 , J Cruz Jurado  8 , N Hindi  2 , X Garcia Del Muro  9
Affiliations

SEOM Clinical Guideline of management of soft-tissue sarcoma (2016)

A López-Pousa et al. Clin Transl Oncol. 2016 Dec.

Abstract

Soft-tissue sarcomas are uncommon and heterogeneous tumors of mesenchymal origin. A soft-tissue mass that is increasing in size, greater than 5 cm, or located under deep fascia are criteria for suspicion of sarcoma. Diagnosis, treatment, and management should preferably be performed by a multidisciplinary team in reference centers. MRI and lung CT scan are mandatory for local and distant assessment. A biopsy indicating histological type and grade is needed previous to the treatment. Wide surgical resection with tumor-free tissue margin is the primary treatment for localized disease. Radiotherapy is indicated in large, deep, high-grade tumors, or after marginal resection not likely of being improved with reexcision. Neoadjuvant and adjuvant chemotherapy improve survival in selected cases, usually in high-grade sarcomas of the extremities. In the case of metastatic disease, patients with exclusive lung metastasis could be considered for surgery. First-line treatment with anthracyclines (or in combination with ifosfamide) is the treatment of choice. New drugs have shown activity in second-line therapy and in specific histological subtypes.

Keywords: Clinical guidelines; Sarcoma; Soft-tissue tumors; Uncommon tumors.

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Conflict of interest statement

The authors declare that they have no conflict of interest relating to the publication of this manuscript and compliance with ethical standards.

Figures

Fig. 1
Fig. 1
Primary management of STS algorithm
See this image and copyright information in PMC

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