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Case Reports
. 1989 Oct 15;64(8):1714-6.
doi: 10.1002/1097-0142(19891015)64:8<1714::aid-cncr2820640826>3.0.co;2-g.

Chronic lymphocytic leukemia with hypothalamic invasion

M Garofalo Jr  1 , R Murali, I Halperin, K Magardician, H F Moussouris, J C Masdeu
Affiliations
Case Reports

Chronic lymphocytic leukemia with hypothalamic invasion

M Garofalo Jr et al. Cancer. .

Abstract

Headaches and a state of confusion developed in a patient with chronic lymphocytic leukemia (CLL). A computed tomography (CT) scan of the head showed a hyperdense lesion in the hypothalamus with obstruction of the foramina of Monro. Leukemic cells with monoclonal lambda B-cell markers were identified in the ventricular fluid at the time of surgical decompression. Similar cells were identified in the peripheral blood. This lesion has not been described as a complication of CLL, a disease that, unlike other leukemias, rarely has central nervous system manifestations.

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