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. 2017:30:58-61.
doi: 10.1016/j.ijscr.2016.11.001. Epub 2016 Nov 11.

Giant primary malignant mesothelioma of the liver: A case report

Ruba Haji Ali  1 , Mohamad Khalife  2 , Ghina El Nounou  2 , Ruba Zuhri Yafi  1 , Hussein Nassar  2 , Zeinab Aidibe  3 , Randa Raad  2 , Rania Abou Eid  2 , Walid Faraj  4
Affiliations

Giant primary malignant mesothelioma of the liver: A case report

Ruba Haji Ali et al. Int J Surg Case Rep. 2017.

Abstract

Introduction: Malignant mesothelioma is a rare neoplasm of mesothelial cells arising most frequently in the pleura or peritoneum and less frequently in the liver.

Case presentation: We present a case of primary hepatic mesothelioma of 41year old woman. She had no history of asbestos exposure or cancer. Abdominal computed tomography (CT) showed 21cm intrahepatic mass in the right lobe with many cystic lesions and few small calcifications. Pathology showed a biphasic cellular pattern. In addition, the tumor cells were positive for Calretinin, Creatine Kinase (CK)5/6, CK7, CKAEI 1/3, Wilms Tumor protein (WT-1), and Vimentin, but were negative for Alpha Feto protein (AFP), Thrombotic Thrombocytopenic Purpura (TTP-1), Anti-Hepatocyte Specific Antigen (HSA), Synaptophysin, CK20, and Homeobox protein (CDx-2).

Discussion: Primary intrahepatic mesothelioma (PIHMM) is not included in the classification of the World Health Organization classification of hepatic tumors. Mesothelial cells are not normally found in the liver, but some reported cases suggest it may grow from the mesothelial cells of the Glisson's capsule.

Conclusion: The probability of hepatic mesothelioma should not be ruled out, even in a young woman without a clear history of asbestos exposure.

Keywords: Case report; Liver; Malignant mesothelioma.

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Figures

Fig. 1
Fig. 1
Coronal Computed Tomography scan. The figure shows a coronal CT triple phase scan of the liver displaying a 21 × 20 × 15.5 cm mass occupying the right lobe with multiple cystic lesions and few small calcifications.
Fig. 2
Fig. 2
Transverse Computed Tomography scan. The figure shows a cross-sectional scan of the mass occupying the right lobe of the liver.
Fig. 3
Fig. 3
Mass displaying well-circumscribed heterogeneous lesion. The figure shows a 24 × 20 × 12 cm mass weighing 4.6 kg. It has a multi-cystic and solid tan-yellow soft cut surface.
See this image and copyright information in PMC

References

    1. Gütgemann I., Standop J., Fischer H.P. Primary intrahepatic malignant mesothelioma of epithelioid type. Virchows Arch. 2006;1(May (5)):655–658. - PubMed
    1. Chabot J.F., Beard D., Langlois A.J., Beard J.W. Mesotheliomas of peritoneum, epicardium, and pericardium induced by strain MC29 avian leukosis virus. Cancer Res. 1970;1(May (5)):1287–1308. - PubMed
    1. Carbone M., Pass H.I. Evolving aspects of mesothelioma carcinogenesis: SV40 and genetic predisposition. J. Thorac. Oncol. 2006;1(February (2)):169–171. - PubMed
    1. Sasaki M., Araki I., Yasui T., Kinoshita M., Itatsu K., Nojima T., Nakanuma Y. Primary localized malignant biphasic mesothelioma of the liver in a patient with asbestosis. World J. Gastroenterol. 2009;7(February (5)):615–621. - PMC - PubMed
    1. Marubayashi S., Ohdan H., Asahara T., Ikeda M., Hinoi T., Fukuma K., Maeda T., Oshiro Y., Shimamoto F., Dohi K. Malignant mesothelioma originating in the hepatic falciform ligament: report of a case. Surg. Today. 1998;28(September (9)):929–931. - PubMed